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    Arene ruthenium dithiolato-carborane complexes for boron neutron capture theory (BNCT)

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    Barry_Journal_of_Organometallic_Chemistry.pdf (1.448Mb)
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    Publication date
    2015
    Author
    Romero-Canelón, I.
    Phoenix, B.
    Pitto-Barry, Anaïs
    Tran, J.
    Soldevila-Barreda, Joan J.
    Kirby, N.
    Green, S.
    Sadler, P.J.
    Barry, Nicolas P.E.
    Keyword
    Arene ruthenium; Carborane; Pluronic; Micelles; Boron neutron capture therapy
    Rights
    © 2015 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/ ).
    Peer-Reviewed
    Yes
    
    Metadata
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    Abstract
    We report the effect of low-energy thermal neutron irradiation on the antiproliferative activities of a highly hydrophobic organometallic arene ruthenium dithiolatoecarborane complex [Ru(p-cymene) (1,2- dicarba-closo-dodecarborane-1,2-dithiolato)] (1), and of its formulation in Pluronic® triblock copolymer P123 coreeshell micelles (RuMs). Complex 1 was highly active, with and without neutron irradiation, towards human ovarian cancer cells (A2780; IC50 0.14 mM and 0.17 mM, respectively) and cisplatinresistant human ovarian cancer cells (A2780cisR; IC50 0.05 and 0.13 mM, respectively). Complex 1 was particularly sensitive to neutron irradiation in A2780cisR cells (2.6 more potent after irradiation compared to non-irradiation). Although less potent, the encapsulated complex 1 as RuMs nanoparticles resulted in higher cellular accumulation (2.5 ), and was sensitive to neutron irradiation in A2780 cells (1.4 more potent upon irradiation compared to non-irradiation).
    URI
    http://hdl.handle.net/10454/11232
    Version
    Published version
    Citation
    Romero-Canelón I, Phoenix B, Pitto-Barry A et al (2015) Arene ruthenium dithiolato-carborane complexes for boron neutron capture theory (BNCT). Journal of Organometallic Chemistry. 796: 17-25.
    Link to publisher’s version
    http://dx.doi.org/10.1016/j.jorganchem.2015.05.011
    Type
    Article
    Collections
    Life Sciences Publications

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