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    Precious metal carborane polymer nanoparticles: characterisation of micellar formulations and anticancer activity

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    Barry_Faraday_Discussions.pdf (522.5Kb)
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    Publication date
    2014
    Author
    Barry, Nicolas P.E.
    Pitto-Barry, Anaïs
    Romero-Canelón, I.
    Tran, J.
    Soldevila-Barreda, Joan J.
    Hands-Portman, I.
    Smith, C.J.
    Kirby, N.
    Dove, A.P.
    O'Reilly, R.K.
    Sadler, P.J.
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    Keyword
    Carborane complexes; Micellar formulations; Anticancer activity
    Rights
    © 2014 The Royal Society of Chemistry. Reproduced in accordance with the publisher's self-archiving policy. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
    Peer-Reviewed
    Yes
    
    Metadata
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    Abstract
    We report the encapsulation of highly hydrophobic 16-electron organometallic ruthenium and osmium carborane complexes [Ru/Os(p-cymene)(1,2-dicarba-closo-dodecarborane-1,2-dithiolate)] (1 and 2) in Pluronic® triblock copolymer P123 core–shell micelles. The spherical nanoparticles RuMs and OsMs, dispersed in water, were characterized by dynamic light scattering (DLS), cryogenic transmission electron microscopy (cryo-TEM), and synchrotron small-angle X-ray scattering (SAXS; diameter ca. 15 and 19 nm, respectively). Complexes 1 and 2 were highly active towards A2780 human ovarian cancer cells (IC50 0.17 and 2.50 μM, respectively) and the encapsulated complexes, as RuMs and OsMs nanoparticles, were less potent (IC50 6.69 μM and 117.5 μM, respectively), but more selective towards cancer cells compared to normal cells.
    URI
    http://hdl.handle.net/10454/11230
    Version
    Published version
    Citation
    Barry NPE, Pitto-Barry A, Romero-Canelón I et al (2014) Precious metal carborane polymer nanoparticles: characterisation of micellar formulations and anticancer activity. Faraday Discussions. 175: 229-240.
    Link to publisher’s version
    http://dx.doi.org/10.1039/C4FD00098F
    Type
    Article
    Collections
    Life Sciences Publications

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