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dc.contributor.authorWright, E.P.*
dc.contributor.authorDay, H.A.*
dc.contributor.authorIbrahim, Ali M.*
dc.contributor.authorKumar, Jeethendra*
dc.contributor.authorBoswell, L.J.E.*
dc.contributor.authorHuguin, C.*
dc.contributor.authorStevenson, C.E.M.*
dc.contributor.authorPors, Klaus*
dc.date.accessioned2017-01-23T14:54:28Z
dc.date.available2017-01-23T14:54:28Z
dc.date.issued2016-12-22
dc.identifier.citationWright EP, Day HA, Ibrahim AM et al (2016) Mitoxantrone and Analogues Bind and Stabilize i-Motif Forming DNA Sequences. Nature Scientific Reports. 6: 39456.en_US
dc.identifier.urihttp://hdl.handle.net/10454/11163
dc.descriptionYesen_US
dc.description.abstractThere are hundreds of ligands which can interact with G-quadruplex DNA, yet very few which target i-motif. To appreciate an understanding between the dynamics between these structures and how they can be affected by intervention with small molecule ligands, more i-motif binding compounds are required. Herein we describe how the drug mitoxantrone can bind, induce folding of and stabilise i-motif forming DNA sequences, even at physiological pH. Additionally, mitoxantrone was found to bind i-motif forming sequences preferentially over double helical DNA. We also describe the stabilisation properties of analogues of mitoxantrone. This offers a new family of ligands with potential for use in experiments into the structure and function of i-motif forming DNA sequences.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttp://dx.doi.org/10.1038/srep39456en_US
dc.rights© 2016 The Authors. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/en_US
dc.subjectDNA; Drug discovery; Drug developmenten_US
dc.titleMitoxantrone and Analogues Bind and Stabilize i-Motif Forming DNA Sequencesen_US
dc.status.refereedYesen_US
dc.date.Accepted2016-10-23
dc.typeArticleen_US
dc.type.versionPublished versionen_US
refterms.dateFOA2018-07-26T09:55:37Z


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