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    Increasing elastin fibre production in a tissue engineered mesh for pelvic floor surgery

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    Publication date
    2014
    Author
    Osman, N.
    Roman, S.
    Sefat, Farshid
    Bullock, A.J.
    Chapple, C.R.
    Keyword
    Pelvic floor; Mesh; Elastin fibre; Biodegradable; Tissue engineering
    Rights
    © 2014 Elsevier. Reproduced in accordance with the publisher's self-archiving policy. This manuscript version is made available under the CC-BY-NC-ND 4.0 license.
    Peer-Reviewed
    yes
    
    Metadata
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    Abstract
    Polypropylene mesh for pelvic floor surgery is associated with serious complications ( e.g. erosion). A biodegradable tissue engineered mesh composed of a polylactic acid (PLA) scaffold seeded with autologous cells is a promising alternative. However, thus far elastin content (important for elastic recoil) in this tissue has been low. We aimed to increase elastin expression and test the resultant tensile properties.
    URI
    http://hdl.handle.net/10454/11154
    Version
    Accepted Manuscript
    Citation
    Osman I, Roman S, Sefat F, Bullock AJ and Chapple CR (2014) Increasing elastin fibre production in a tissue engineered mesh for pelvic floor surgery. European Urology Supplements. 13(1): 483.
    Link to publisher’s version
    http://dx.doi.org/10.1016/S1569-9056(14)60476-0
    Type
    Article
    Collections
    Engineering and Informatics Publications

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