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dc.contributor.authorDenniss, Jonathan*
dc.contributor.authorTurpin, A.*
dc.contributor.authorMcKendrick, A.M.*
dc.date.accessioned2017-01-11T11:52:31Z
dc.date.available2017-01-11T11:52:31Z
dc.date.issued2014-12
dc.identifier.citationDenniss J, Turpin A and McKendrick AM (2014) Visual Contrast Detection Cannot be Predicted from Surrogate Measures of Retinal Ganglion Cell Number and Sampling Density in Healthy Young Adults. Investigative Ophthalmology and Visual Science. 55(12): 7804-7813.en_US
dc.identifier.urihttp://hdl.handle.net/10454/11094
dc.descriptionyesen_US
dc.description.abstractPurpose.: To establish whether a clinically exploitable relationship exists between surrogate measures of retinal ganglion cell number and functional sampling density and visual contrast sensitivity in healthy young eyes. Methods.: Psychometric functions for contrast detection were measured at 9° eccentricity in superior and inferior visual field from 20 healthy adults (age 23–43, median 26 years). Functions were compared with corresponding localized regions of retinal nerve fiber layer (RNFL) thickness measured by optical coherence tomography, a surrogate of retinal ganglion cell number, and to grating resolution acuity, a psychophysical surrogate of retinal ganglion cell sampling density. Correlations between psychometric function parameters and retinal ganglion cell surrogates were measured by Spearman's rank correlation. Results.: All measures exhibited a 2- to 4-fold variation in our sample. Despite this, correlations between measures were weak. Correlations between psychometric function parameters (threshold, spread) and RNFL thickness ranged in magnitude from 0.05 to 0.19 (P = 0.43–0.85). Grating resolution was sampling limited for 16 of 20 participants in superior visual field, and for 12 of 20 participants in inferior visual field. Correlations between psychometric function parameters and grating resolution acuities ranged in magnitude from 0.05 to 0.36 (P = 0.12–0.85) when all data were considered, and from 0.06 to 0.36 (P = 0.26–0.87) when only sampling-limited data were considered. Conclusions.: Despite considerable variation in both psychometric functions for contrast detection and surrogate measures of retinal ganglion cell number and sampling density among healthy eyes, relationships between these measures are weak. These relationships are unlikely to be exploitable for improving clinical tests in healthy populations.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttp://dx.doi.org/10.1167/iovs.14-15339en_US
dc.rights© 2014 ARVO. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. (http://creativecommons.org/licenses/by-nc-nd/4.0/).en_US
dc.subjectVisual contrast detection; Surrogate measures; Retinal ganglion cell number; Sampling density; Young adultsen_US
dc.titleVisual Contrast Detection Cannot Be Predicted From Surrogate Measures of Retinal Ganglion Cell Number and Sampling Density in Healthy Young Adultsen_US
dc.status.refereedyesen_US
dc.typeArticleen_US
dc.type.versionPublished versionen_US
refterms.dateFOA2018-07-25T15:56:15Z


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