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    Visual Contrast Detection Cannot Be Predicted From Surrogate Measures of Retinal Ganglion Cell Number and Sampling Density in Healthy Young Adults

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    Publication date
    2014-12
    Author
    Denniss, Jonathan
    Turpin, A.
    McKendrick, A.M.
    Keyword
    Visual contrast detection; Surrogate measures; Retinal ganglion cell number; Sampling density; Young adults
    Rights
    © 2014 ARVO. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. (http://creativecommons.org/licenses/by-nc-nd/4.0/).
    Peer-Reviewed
    yes
    
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    Abstract
    Purpose.: To establish whether a clinically exploitable relationship exists between surrogate measures of retinal ganglion cell number and functional sampling density and visual contrast sensitivity in healthy young eyes. Methods.: Psychometric functions for contrast detection were measured at 9° eccentricity in superior and inferior visual field from 20 healthy adults (age 23–43, median 26 years). Functions were compared with corresponding localized regions of retinal nerve fiber layer (RNFL) thickness measured by optical coherence tomography, a surrogate of retinal ganglion cell number, and to grating resolution acuity, a psychophysical surrogate of retinal ganglion cell sampling density. Correlations between psychometric function parameters and retinal ganglion cell surrogates were measured by Spearman's rank correlation. Results.: All measures exhibited a 2- to 4-fold variation in our sample. Despite this, correlations between measures were weak. Correlations between psychometric function parameters (threshold, spread) and RNFL thickness ranged in magnitude from 0.05 to 0.19 (P = 0.43–0.85). Grating resolution was sampling limited for 16 of 20 participants in superior visual field, and for 12 of 20 participants in inferior visual field. Correlations between psychometric function parameters and grating resolution acuities ranged in magnitude from 0.05 to 0.36 (P = 0.12–0.85) when all data were considered, and from 0.06 to 0.36 (P = 0.26–0.87) when only sampling-limited data were considered. Conclusions.: Despite considerable variation in both psychometric functions for contrast detection and surrogate measures of retinal ganglion cell number and sampling density among healthy eyes, relationships between these measures are weak. These relationships are unlikely to be exploitable for improving clinical tests in healthy populations.
    URI
    http://hdl.handle.net/10454/11094
    Version
    Published version
    Citation
    Denniss J, Turpin A and McKendrick AM (2014) Visual Contrast Detection Cannot be Predicted from Surrogate Measures of Retinal Ganglion Cell Number and Sampling Density in Healthy Young Adults. Investigative Ophthalmology and Visual Science. 55(12): 7804-7813.
    Link to publisher’s version
    http://dx.doi.org/10.1167/iovs.14-15339
    Type
    Article
    Collections
    Life Sciences Publications

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