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dc.contributor.authorDanthurebandara, V.M.*
dc.contributor.authorSharpe, G.P.*
dc.contributor.authorHutchison, D.M.*
dc.contributor.authorDenniss, Jonathan*
dc.contributor.authorNicolela, M.T.*
dc.contributor.authorMcKendrick, A.M.*
dc.contributor.authorTurpin, A.*
dc.contributor.authorChauhan, B.C.*
dc.date.accessioned2017-01-11T11:40:29Z
dc.date.available2017-01-11T11:40:29Z
dc.date.issued2015
dc.identifier.citationDanthurebandara V, Sharpe GP, Hutchison DM, Denniss J, Nicolela MT, Turpin A, McKendrick AM and Chauhan BC (2015) Enhanced structure-function relationship in glaucoma with an anatomically and geometrically accurate neuroretinal rim measurement. Investigative Ophthalmology & Visual Science. 56: 98-105.en_US
dc.identifier.urihttp://hdl.handle.net/10454/11091
dc.descriptionyesen_US
dc.description.abstractPurpose: To evaluate the structure–function relationship between disc margin–based rim area (DM-RA) obtained with confocal scanning laser tomography (CSLT), Bruch's membrane opening–based horizontal rim width (BMO-HRW), minimum rim width (BMO-MRW), peripapillary retinal nerve fiber layer thickness (RNFLT) obtained with spectral-domain optical coherence tomography (SD-OCT), and visual field sensitivity. Methods: We examined 151 glaucoma patients with CSLT, SD-OCT, and standard automated perimetry on the same day. Optic nerve head (ONH) and RNFL with SD-OCT were acquired relative to a fixed coordinate system (acquired image frame [AIF]) and to the eye-specific fovea-BMO center (FoBMO) axis. Visual field locations were mapped to ONH and RNFL sectors with fixed Garway-Heath (VFGH) and patient-specific (VFPS) maps customized for various biometric parameters. Results: Globally and sectorally, the structure–function relationships between DM-RA and VFGH, BMO-HRWAIF and VFGH, and BMO-HRWFoBMO and VFPS were equally weak. The R2 for the relationship between DM-RA and VFGH ranged from 0.1% (inferonasal) to 11% (superotemporal) whereas that between BMO-HRWAIF and VFGH ranged from 0.1% (nasal) to 10% (superotemporal). Relatively stronger global and sectoral structure–function relationships with BMO-MRWAIF and with BMO-MRWFoBMO were obtained. The R2 between BMO-MRWAIF and VFGH ranged from 5% (nasal) to 30% (superotemporal), whereas that between BMO-MRWFoBMO and VFPS ranged from 5% (nasal) to 25% (inferotemporal). The structure–function relationship with RNFLT was not significantly different from that with BMO-MRW, regardless of image acquisition method. Conclusions: The structure–function relationship was enhanced with BMO-MRW compared with the other neuroretinal rim measurements, due mainly to its geometrically accurate properties.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttp://dx.doi.org/10.1167/iovs.14-15375en_US
dc.rights© 2015 ARVO. Reproduced in accordance with the publisher's self-archiving policy.en_US
dc.subjectGlaucoma; Structure-function relationship; Neuroretinal rim measurementen_US
dc.titleEnhanced structure-function relationship in glaucoma with an anatomically and geometrically accurate neuroretinal rim measurementen_US
dc.status.refereedyesen_US
dc.typeArticleen_US
dc.type.versionPublished versionen_US
refterms.dateFOA2018-07-25T15:56:07Z


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