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dc.contributor.authorDenniss, Jonathan*
dc.contributor.authorTurpin, A.*
dc.contributor.authorMcKendrick, A.M.*
dc.date.accessioned2017-01-11T10:24:44Z
dc.date.available2017-01-11T10:24:44Z
dc.date.issued2014
dc.identifier.citationDenniss J, Turpin A and McKendrick AM (2014) Individualized Structure-Function Mapping for Glaucoma: Practical Constraints on Map Resolution for Clinical and Research Applications. Investigative Ophthalmology & Visual Science. 55: 1985-1993.en_US
dc.identifier.urihttp://hdl.handle.net/10454/11089
dc.descriptionyesen_US
dc.description.abstractPurpose: We have developed customized maps that relate visual field and optic nerve head (ONH) regions according to individual anatomy. In this study, we aimed to determine feasible map resolution for research use, and to make a principled recommendation of sector size for clinical applications. Methods: Measurement variability in fovea–ONH distance and angle was estimated from 10 repeat OCT scans of 10 healthy people. Errors in estimating axial length from refractive error were determined from published data. Structure–function maps were generated, and customized to varied clinically-plausible anatomical parameters. For each parameter set (n = 210), 200 maps were generated by sampling from measurement/estimation error distributions. Mapped 1° sectors at each visual field location from each parameter set were normalized to difference from their mean. Variation (90% ranges) in normalized mapped sectors represents the precision of individualized maps. Results: Standard deviations of repeated measures of fovea–ONH distance and angle were 61 μm and 0.97° (coefficients of variation 1.3% and 12.0%, respectively). Neither measure varied systematically with mean (Spearmans's ρ = 0.26, P = 0.47 for distance, ρ = −0.31, P = 0.39 for angle). Variation (90% ranges) in normalized mapped sectors varied across the visual field and ranged from 3° to 18° when axial length was measured accurately, and from 6° to 32° when axial length was estimated from refractive error. Conclusions: The 90% ranges represent the minimum feasible ONH sector size at each visual field location. For clinical use an easily interpretable scheme of 30° sectors is suggested.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttp://dx.doi.org/10.1167/iovs.13-13758en_US
dc.rights© 2014 ARVO. Reproduced in accordance with the publisher's self-archiving policy.en_US
dc.subjectStructure–function: Visual field; Optic nerve head; Glaucoma; Perimetryen_US
dc.titleIndividualized Structure–Function Mapping for Glaucoma: Practical Constraints on Map Resolution for Clinical and Research Applicationsen_US
dc.status.refereedyesen_US
dc.typeArticleen_US
dc.type.versionPublished versionen_US
refterms.dateFOA2018-07-25T15:56:24Z


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