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    Structure–Function Mapping: Variability and Conviction in Tracing Retinal Nerve Fiber Bundles and Comparison to a Computational Model

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    Publication date
    2014
    Author
    Denniss, Jonathan
    Turpin, A.
    Tanabe, F.
    Matsumoto, C.
    McKendrick, A.M.
    Keyword
    Structure–function; Glaucoma; Visual field; Optic nerve head; Mapping
    Rights
    © 2014 ARVO. Reproduced in accordance with the publisher's self-archiving policy.
    Peer-Reviewed
    yes
    
    Metadata
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    Abstract
    Purpose: We evaluated variability and conviction in tracing paths of retinal nerve fiber bundles (RNFBs) in retinal images, and compared traced paths to a computational model that produces anatomically-customized structure–function maps. Methods: Ten retinal images were overlaid with 24-2 visual field locations. Eight clinicians and 6 naïve observers traced RNFBs from each location to the optic nerve head (ONH), recording their best estimate and certain range of insertion. Three clinicians and 2 naïve observers traced RNFBs in 3 images, 3 times, 7 to 19 days apart. The model predicted 10° ONH sectors relating to each location. Variability and repeatability in best estimates, certain range width, and differences between best estimates and model-predictions were evaluated. Results: Median between-observer variability in best estimates was 27° (interquartile range [IQR] 20°–38°) for clinicians and 33° (IQR 22°–50°) for naïve observers. Median certain range width was 30° (IQR 14°–45°) for clinicians and 75° (IQR 45°–180°) for naïve observers. Median repeatability was 10° (IQR 5°–20°) for clinicians and 15° (IQR 10°–29°) for naïve observers. All measures were worse further from the ONH. Systematic differences between model predictions and best estimates were negligible; median absolute differences were 17° (IQR 9°–30°) for clinicians and 20° (IQR 10°–36°) for naïve observers. Larger departures from the model coincided with greater variability in tracing. Conclusions: Concordance between the model and RNFB tracing was good, and greatest where tracing variability was lowest. When RNFB tracing is used for structure–function mapping, variability should be considered.
    URI
    http://hdl.handle.net/10454/11088
    Version
    Published version
    Citation
    Denniss J, Turpin A, Tanabe F, Matsumoto C and McKendrick AM. (2014) Structure-Function Mapping: Variability and Conviction in Tracing Retinal Nerve Fibre Bundles and Comparison to a Computational Model. Investigative Ophthalmology & Visual Science. 55: 728-736.
    Link to publisher’s version
    http://dx.doi.org/10.1167/iovs.13-13142
    Type
    Article
    Collections
    Life Sciences Publications

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