Show simple item record

dc.contributor.authorUgbode, Christopher I.*
dc.contributor.authorYuhan, H.*
dc.contributor.authorWhalley, B.J.*
dc.contributor.authorPeers, C.*
dc.contributor.authorRattray, Marcus*
dc.contributor.authorDallas, M.*
dc.date.accessioned2016-12-19T15:07:39Z
dc.date.available2016-12-19T15:07:39Z
dc.date.issued2017
dc.identifier.citationUgbode C, Yuhan H, Whalley B et al (2017) Astrocytic Transporters in Alzheimer’s disease. Biochemical Journal. 474(3): 333-355.en_US
dc.identifier.urihttp://hdl.handle.net/10454/11004
dc.descriptionYesen_US
dc.description.abstractAstrocytes play a fundamental role in maintaining the health and function of the central nervous system. Increasing evidence indicates that astrocytes undergo both cellular and molecular changes at an early stage in neurological diseases, including Alzheimer’s disease. These changes may reflect a change from a neuroprotective to a neurotoxic phenotype. Given the lack of current disease modifying therapies for Alzheimer’s disease, astrocytes have become an interesting and viable target for therapeutic intervention. The astrocyte transport system covers a diverse array of proteins involved in metabolic support, neurotransmission and synaptic architecture. Therefore, specific targeting of individual transporter families has the potential to suppress neurodegeneration, a characteristic hallmark of Alzheimer’s disease. A small number of the four hundred transporter superfamilies’ are expressed in astrocytes, with evidence highlighting a fraction of these are implicated in Alzheimer’s disease. Here we review the current evidence for six astrocytic transporter subfamilies involved in Alzheimer’s disease, as reported in both animal and human studies. This review confirms that astrocytes are indeed a viable target, highlights the complexities of studying astrocytes and provides future directives to exploit the potential of astrocytes in tackling Alzheimer’s disease.en_US
dc.description.sponsorshipBBSRC, Alzheimer's Society, Motor Neuron Disease Associationen_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttps://doi.org/10.1042/BCJ20160505
dc.rights(c) 2017 The Authors. Full-text reproduced in accordance with the publisher's self-archiving policy.en_US
dc.subjectAstrocyte; Amyloid beta; Neurotransmitter transport; Azlheimer's diseaseen_US
dc.titleAstrocytic Transporters in Alzheimer’s diseaseen_US
dc.status.refereedYesen_US
dc.date.Accepted2016
dc.date.Accepted2016-11-29
dc.typeArticleen_US
dc.type.versionAccepted Manuscripten_US
refterms.dateFOA2018-01-21T00:00:00Z


Item file(s)

Thumbnail
Name:
dallas_et_al_2017.pdf
Size:
918.6Kb
Format:
PDF
Description:
Keep suppressed - has older cover ...
Thumbnail
Name:
dallas_et_al_2017.pdf
Size:
935.4Kb
Format:
PDF

This item appears in the following Collection(s)

Show simple item record