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dc.contributor.authorRanjan, S.*
dc.contributor.authorDevarapalli, R.*
dc.contributor.authorKundu, S.*
dc.contributor.authorVangala, Venu R.*
dc.contributor.authorGhosh, A.*
dc.contributor.authorReddy, C.A.*
dc.date.accessioned2016-12-15T13:55:52Z
dc.date.available2016-12-15T13:55:52Z
dc.date.issued2017-04-05
dc.identifier.citationRanjan S, Devarapalli R, Kundu S et al (2017) Three new hydrochlorothiazide cocrystals: Structural analyses and solubility studies. Journal of Molecular Structure. 1133: 405-410.
dc.identifier.urihttp://hdl.handle.net/10454/10975
dc.descriptionYes
dc.description.abstractHydrochlorothiazide (HCT) is a diuretic BCS class IV drug with poor aqueous solubility and low permeability leading to poor oral absorption. The present work explores the cocrystallization technique to enhance the aqueous solubility of HCT. Three new cocrystals of HCT with water soluble coformers phenazine (PHEN), 4-dimethylaminopyridine (DMAP) and picolinamide (PICA) were prepared successfully by solution crystallization method and characterized by single crystal X-ray diffraction (SCXRD), powder X-ray diffraction (PXRD), fourier transform –infraredspectroscopy (FT-IR), differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). Structural characterization revealed that the cocrystals with PHEN, DMAP and PICA exists in P21/n, P21/c and P21/n space groups, respectively. The improved solubility of HCT-DMAP (4 fold) and HCT-PHEN (1.4 fold) cocrystals whereas decreased solubility of HCT-PICA (0.5 fold) as compared to the free drug were determined after 4 h in phosphate buffer, pH 7.4, at 25 °C by using shaking flask method. HCT-DMAP showed a significant increase in solubility than all previously reported cocrystals of HCT suggest the role of a coformer. The study demonstrates that the selection of coformer could have pronounced impact on the physicochemical properties of HCT and cocrystallization can be a promising approach to improve aqueous solubility of drugs.
dc.language.isoen
dc.rights© 2017 Elsevier. Reproduced in accordance with the publisher's selfarchiving policy. This manuscript version is made available under the CC-BY-NC-ND 4.0 license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
dc.subjectCrystal engineering
dc.subjectCocrystal
dc.subjectSolubility
dc.subjectThermal analysis
dc.subjectStructural analysis
dc.titleThree new hydrochlorothiazide cocrystals: Structural analyses and solubility studies
dc.status.refereedYes
dc.date.Accepted2016-12-06
dc.date.application2016-12-09
dc.typeArticle
dc.type.versionAccepted manuscript
dc.identifier.doihttps://doi.org/10.1016/j.molstruc.2016.12.019
dc.rights.licenseCC-BY-NC-ND
refterms.dateFOA2017-12-10T00:00:00Z
dc.openaccess.statusopenAccess


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