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dc.contributor.authorGilbert, M.T.P.*
dc.contributor.authorTomsho, L.P.*
dc.contributor.authorRendulic, S.*
dc.contributor.authorPackard, M.*
dc.contributor.authorDrautz, D.I.*
dc.contributor.authorSher, A.*
dc.contributor.authorTikhonov, A.*
dc.contributor.authorDalen, L.*
dc.contributor.authorKuznetsova, T.*
dc.contributor.authorKosintsev, P.*
dc.contributor.authorCampos, P.F.*
dc.contributor.authorHigham, T.F.G.*
dc.contributor.authorCollins, M.J.*
dc.contributor.authorWilson, Andrew S.*
dc.contributor.authorShidlovskiy, F.*
dc.contributor.authorBuigues, B.*
dc.contributor.authorEricson, P.G.*
dc.contributor.authorGermonpre, M.*
dc.contributor.authorGötherström, A.*
dc.contributor.authorIacumin, P.*
dc.contributor.authorNikolaev, V.*
dc.contributor.authorNowak-Kemp, M.*
dc.contributor.authorWillerslev, E.*
dc.contributor.authorKnight, J.R.*
dc.contributor.authorIrzyk, G.P.*
dc.contributor.authorPerbost, C.S.*
dc.contributor.authorFredrikson, K.M.*
dc.contributor.authorHarkins, T.T.*
dc.contributor.authorSheridan, S.*
dc.contributor.authorMiller, W.*
dc.contributor.authorSchuster, S.C.*
dc.date.accessioned2016-12-15T08:56:16Z
dc.date.available2016-12-15T08:56:16Z
dc.date.issued2007-09-28
dc.identifier.citationGilbert MT, Tomsho LP, Rendulic S et al (2007) Whole-genome shotgun sequencing of mitochondria from ancient hair shafts. Science. 317(5846): 1927-1930.en_US
dc.identifier.urihttp://hdl.handle.net/10454/10946
dc.descriptionNoen_US
dc.description.abstractAlthough the application of sequencing-by-synthesis techniques to DNA extracted from bones has revolutionized the study of ancient DNA, it has been plagued by large fractions of contaminating environmental DNA. The genetic analyses of hair shafts could be a solution: We present 10 previously unexamined Siberian mammoth (Mammuthus primigenius) mitochondrial genomes, sequenced with up to 48-fold coverage. The observed levels of damage-derived sequencing errors were lower than those observed in previously published frozen bone samples, even though one of the specimens was >50,000 14C years old and another had been stored for 200 years at room temperature. The method therefore sets the stage for molecular-genetic analysis of museum collections.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttp://dx.doi.org/10.1126/science.1146971en_US
dc.subjectWhole-genome shotgun sequencing; Mitochondria; Hair; Human remains; DNAen_US
dc.titleWhole-genome shotgun sequencing of mitochondria from ancient hair shaftsen_US
dc.status.refereedYesen_US
dc.typeArticleen_US
dc.type.versionNo full-text in the repositoryen_US


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