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dc.contributor.authorBengtsson, C.F.*
dc.contributor.authorOlsen, M.E.*
dc.contributor.authorBrandt, L.O.*
dc.contributor.authorBertelsen, M.F.*
dc.contributor.authorWillerslev, E.*
dc.contributor.authorTobin, Desmond J.*
dc.contributor.authorWilson, Andrew S.*
dc.contributor.authorGilbert, M.T.P.*
dc.date.accessioned2016-12-14T17:25:43Z
dc.date.available2016-12-14T17:25:43Z
dc.date.issued2012
dc.identifier.citationBengtsson CF, Olsen ME, Brandt LO et al (2012) DNA from keratinous tissue. Part I: Hair and nail. Annals of Anatomy. 194(1): 17-25.en_US
dc.identifier.urihttp://hdl.handle.net/10454/10932
dc.descriptionNoen_US
dc.description.abstractKeratinous tissues such as nail, hair, horn, scales and feather have been used as a source of DNA for over 20 years. Particular benefits of such tissues include the ease with which they can be sampled, the relative stability of DNA in such tissues once sampled, and, in the context of ancient genetic analyses, the fact that sampling generally causes minimal visual damage to valuable specimens. Even when freshly sampled, however, the DNA quantity and quality in the fully keratinized parts of such tissues is extremely poor in comparison to other tissues such as blood and muscle – although little systematic research has been undertaken to characterize how such degradation may relate to sample source. In this review paper we present the current understanding of the quality and limitations of DNA in two key keratinous tissues, nail and hair. The findings indicate that although some fragments of nuclear and mitochondrial DNA appear to be present in almost all hair and nail samples, the quality of DNA, both in quantity and length of amplifiable DNA fragments, vary considerably not just by species, but by individual, and even within individual between hair types.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttp://dx.doi.org/10.1016/j.aanat.2011.03.013en_US
dc.subjectAncient DNA; Degradation; Hair; Keratinisation; Mitochondrial DNA; Nail; Nuclear DNA; REF 2014en_US
dc.titleDNA from keratinous tissue. Part I: Hair and nailen_US
dc.status.refereedYesen_US
dc.typeArticleen_US
dc.type.versionNo full-text in the repositoryen_US


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