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dc.contributor.authorEl-Tanani, Mohamed*
dc.contributor.authorDakir, El-Habib*
dc.contributor.authorRaynor, Bethany*
dc.contributor.authorMorgan, Richard*
dc.date.accessioned2016-11-30T11:51:48Z
dc.date.available2016-11-30T11:51:48Z
dc.date.issued2016-03-14
dc.identifier.citationEl-Tanani M, Dakir E, Raynor B et al (2016) Mechanisms of Nuclear Export in Cancer and Resistance to Chemotherapy. Cancers. 8(3): 35en_US
dc.identifier.urihttp://hdl.handle.net/10454/10859
dc.descriptionYesen_US
dc.description.abstractTumour suppressor proteins, such as p53, BRCA1, and ABC, play key roles in preventing the development of a malignant phenotype, but those that function as transcriptional regulators need to enter the nucleus in order to function. The export of proteins between the nucleus and cytoplasm is complex. It occurs through nuclear pores and exported proteins need a nuclear export signal (NES) to bind to nuclear exportin proteins, including CRM1 (Chromosomal Region Maintenance protein 1), and the energy for this process is provided by the RanGTP/RanGDP gradient. Due to the loss of DNA repair and cell cycle checkpoints, drug resistance is a major problem in cancer treatment, and often an initially successful treatment will fail due to the development of resistance. An important mechanism underlying resistance is nuclear export, and a number of strategies that can prevent nuclear export may reverse resistance. Examples include inhibitors of CRM1, antibodies to the nuclear export signal, and alteration of nuclear pore structure. Each of these are considered in this review.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttp://dx.doi.org/10.3390/cancers8030035en_US
dc.rights© 2016 The Authors. This is an Open Access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/)en_US
dc.subjectNuclear export; CRM1; Ran; Nucleocytoplasmic transporten_US
dc.titleMechanisms of Nuclear Export in Cancer and Resistance to Chemotherapyen_US
dc.status.refereedYesen_US
dc.date.Accepted2016-03-08
dc.typeArticleen_US
dc.type.versionPublished versionen_US
refterms.dateFOA2018-07-26T09:20:58Z


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