Show simple item record

dc.contributor.authorRoss, A.W.*
dc.contributor.authorRussell, L.*
dc.contributor.authorHelfer, Gisela*
dc.contributor.authorThomson, L.M.*
dc.contributor.authorDalby, M.J.*
dc.contributor.authorMorgan, P.J.*
dc.date.accessioned2016-11-28T16:48:04Z
dc.date.available2016-11-28T16:48:04Z
dc.date.issued2015-03-19
dc.identifier.citationRoss AW, Russell L, Helfer G, Thomson LM, Dalby M and Morgan PJ (2015) Photoperiod regulates lean mass accretion, but not adiposity, in growing F344 rats fed a high fat diet. PLoS One. 10(3): e0119763.en_US
dc.identifier.urihttp://hdl.handle.net/10454/10840
dc.descriptionyesen_US
dc.description.abstractIn this study the effects of photoperiod and diet, and their interaction, were examined for their effects on growth and body composition in juvenile F344 rats over a 4-week period. On long (16L:8D), relative to short (8L:16D), photoperiod food intake and growth rate were increased, but percentage adiposity remained constant (ca 3-4%). On a high fat diet (HFD), containing 22.8% fat (45% energy as fat), food intake was reduced, but energy intake increased on both photoperiods. This led to a small increase in adiposity (up to 10%) without overt change in body weight. These changes were also reflected in plasma leptin and lipid levels. Importantly while both lean and adipose tissue were strongly regulated by photoperiod on a chow diet, this regulation was lost for adipose, but not lean tissue, on HFD. This implies that a primary effect of photoperiod is the regulation of growth and lean mass accretion. Consistent with this both hypothalamic GHRH gene expression and serum IGF-1 levels were photoperiod dependent. As for other animals and humans, there was evidence of central hyposomatotropism in response to obesity, as GHRH gene expression was suppressed by the HFD. Gene expression of hypothalamic AgRP and CRH, but not NPY nor POMC, accorded with the energy balance status on long and short photoperiod. However, there was a general dissociation between plasma leptin levels and expression of these hypothalamic energy balance genes. Similarly there was no interaction between the HFD and photoperiod at the level of the genes involved in thyroid hormone metabolism (Dio2, Dio3, TSHβ or NMU), which are important mediators of the photoperiodic response. These data suggest that photoperiod and HFD influence body weight and body composition through independent mechanisms but in each case the role of the hypothalamic energy balance genes is not predictable based on their known function.en_US
dc.description.sponsorshipScottish Government (Rural and Environment Science and Analytical Services Division, http://www.scotland.gov.uk/), AWR LR LMT PJM and the BBSRC, (http://www.bbsrc.ac.uk/home/home.aspx, grant BB/K001043/1), AWR GH PJMen_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttp://dx.doi.org/10.1371/journal.pone.0119763en_US
dc.rights© 2015 The Authors. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are crediteden_US
dc.subjectPhotoperiod; High fat diet; Food intake; Rat model; Body weight; Body compositionen_US
dc.titlePhotoperiod Regulates Lean Mass Accretion, but Not Adiposity, in Growing F344 Rats Fed a High Fat Dieten_US
dc.status.refereedyesen_US
dc.date.Accepted2015-01-16
dc.typeArticleen_US
dc.type.versionPublished versionen_US
refterms.dateFOA2018-07-26T09:53:13Z


Item file(s)

Thumbnail
Name:
journal.pone.0119763.PDF
Size:
1.005Mb
Format:
PDF
Description:
Main article

This item appears in the following Collection(s)

Show simple item record