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dc.contributor.authorMahmah, O.*
dc.contributor.authorTabbakh, R.*
dc.contributor.authorKelly, Adrian L.*
dc.contributor.authorParadkar, Anant R*
dc.date.accessioned2016-11-28T15:11:48Z
dc.date.available2016-11-28T15:11:48Z
dc.date.issued2014
dc.identifier.citationMahmah O, Tabbakh R, Kelly AL et al (2014) A comparative study of the effect of spray drying and hot-melt extrusion on the properties of amorphous solid dispersions containing felodipine. Journal of Pharmaceutical Pharmacology. 66(2): 275-284.
dc.identifier.urihttp://hdl.handle.net/10454/10730
dc.descriptionNo
dc.description.abstractOBJECTIVES: To compare the properties of solid dispersions of felodipine for oral bioavailability enhancement using two different polymers, polyvinylpyrrolidone (PVP) and hydroxypropyl methylcellulose acetate succinate (HPMCAS), by hot-melt extrusion (HME) and spray drying. METHODS: Felodipine solid dispersions were prepared by HME and spray drying techniques. PVP and HPMCAS were used as polymer matrices at different drug : polymer ratios (1 : 1, 1 : 2 and 1 : 3). Detailed characterization was performed using differential scanning calorimetry, powder X-ray diffractometry, scanning electron microscopy and in-vitro dissolution testing. Dissolution profiles were evaluated in the presence of sodium dodecyl sulphate. Stability of different solid dispersions was studied under accelerated conditions (40 degrees C/75% RH) over 8 weeks. KEY FINDINGS: Spray-dried formulations were found to release felodipine faster than melt extruded formulations for both polymer matrices. Solid dispersions containing HMPCAS exhibited higher drug release rates and better wettability than those produced with a PVP matrix. No significant differences in stability were observed except with HPMCAS at a 1 : 1 ratio, where crystallization was detected in spray-dried formulations. CONCLUSIONS: Solid dispersions of felodipine produced by spray drying exhibited more rapid drug release than corresponding melt extruded formulations, although in some cases improved stability was observed for melt extruded formulations.
dc.subjectBiological availability
dc.subjectChemistry
dc.subjectDesiccation
dc.subjectDrug carriers
dc.subjectDrug compounding
dc.subjectDrug stability
dc.subjectFelodipine
dc.subjectHot temperature
dc.subjectHumans
dc.subjectMethylcellulose
dc.subjectPovidone
dc.subjectSolubility
dc.subjectSolutions
dc.subjectWettability
dc.subjectDissolution rate
dc.subjectHot-melt extrusion
dc.subjectSolid dispersion
dc.subjectSpray drying
dc.subjectStability
dc.titleA comparative study of the effect of spray drying and hot-melt extrusion on the properties of amorphous solid dispersions containing felodipine
dc.status.refereedYes
dc.typeArticle
dc.type.versionNo full-text in the repository
dc.identifier.doihttps://doi.org/10.1111/jphp.12099


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