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dc.contributor.authorBeggs, Clive B.*
dc.contributor.authorShepherd, Simon J.*
dc.contributor.authorZamboni, P.*
dc.date.accessioned2016-11-23T18:23:19Z
dc.date.available2016-11-23T18:23:19Z
dc.date.issued2014
dc.identifier.citationBeggs CB, Shepherd S and Zamboni P (2014) Cerebral venous outflow resistance and interpretation of cervical plethysmography data with respect to the diagnosis of chronic cerebrospinal venous insufficiency. Phlebology. 29(3): 191-199.
dc.identifier.urihttp://hdl.handle.net/10454/10606
dc.descriptionNo
dc.description.abstractPURPOSE: To investigate cerebrospinal fluid (CSF) dynamics in the aqueduct of Sylvius (AoS) in chronic cerebrospinal venous insufficiency (CCSVI)-positive and -negative healthy individuals using cine phase contrast imaging. MATERIALS AND METHODS: Fifty-one healthy individuals (32 CCSVI-negative and 19 age-matched CCSVI-positive subjects) were examined using Doppler sonography (DS). Diagnosis of CCSVI was established if subjects fulfilled >/=2 venous hemodynamic criteria on DS. CSF flow and velocity measures were quantified using a semiautomated method and compared with clinical and routine 3T MRI outcomes. RESULTS: CCSVI was associated with increased CSF pulsatility in the AoS. Net positive CSF flow was 32% greater in the CCSVI-positive group compared with the CCSVI-negative group (P = 0.008). This was accompanied by a 28% increase in the mean aqueductal characteristic signal (ie, the AoS cross-sectional area over the cardiac cycle) in the CCSVI-positive group compared with the CCSVI-negative group (P = 0.021). CONCLUSION: CSF dynamics are altered in CCSVI-positive healthy individuals, as demonstrated by increased pulsatility. This is accompanied by enlargement of the AoS, suggesting that structural changes may be occurring in the brain parenchyma of CCSVI-positive healthy individuals.
dc.relation.isreferencedbyhttps://doi.org/10.1002/jmri.24468
dc.subjectAdult
dc.subject; Aged
dc.subject; Cerebral aqueduct
dc.subject; Cerebrospinal fluid
dc.subject; Cerebrovascular disorders
dc.subject; Cluster analysis
dc.subject; Female
dc.subject; Humans
dc.subject; Hydrocephalus
dc.subject; Image processing
dc.subject; Lateral ventricles
dc.subject; Magnetic Resonance Imaging
dc.subject; Male
dc.subject; Middle aged
dc.subject; Multiple Sclerosis
dc.subject; Pulsatile flow
dc.subject; Reference values
dc.subject; Software
dc.subject; Statistics as topic
dc.subject; Ultrasonography
dc.subject; Venous insufficiency
dc.subject; Ccsvi
dc.subject; CSF dynamics
dc.subject; Aqueduct of Sylvius
dc.subject; Cerebral venous outflow
dc.subject; Healthy individuals
dc.subject; Lateral ventricle volume
dc.titleCerebral venous outflow resistance and interpretation of cervical plethysmography data with respect to the diagnosis of chronic cerebrospinal venous insufficiency
dc.status.refereedYes
dc.typeArticle
dc.type.versionNo full-text in the repository


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