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    Cerebral venous outflow resistance and interpretation of cervical plethysmography data with respect to the diagnosis of chronic cerebrospinal venous insufficiency

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    Publication date
    2014
    Author
    Beggs, Clive B.
    Shepherd, Simon J.
    Zamboni, P.
    Keyword
    Adult
    ; Aged
    ; Cerebral aqueduct
    ; Cerebrospinal fluid
    ; Cerebrovascular disorders
    ; Cluster analysis
    ; Female
    ; Humans
    ; Hydrocephalus
    ; Image processing
    ; Lateral ventricles
    ; Magnetic Resonance Imaging
    ; Male
    ; Middle aged
    ; Multiple Sclerosis
    ; Pulsatile flow
    ; Reference values
    ; Software
    ; Statistics as topic
    ; Ultrasonography
    ; Venous insufficiency
    ; Ccsvi
    ; CSF dynamics
    ; Aqueduct of Sylvius
    ; Cerebral venous outflow
    ; Healthy individuals
    ; Lateral ventricle volume
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    Peer-Reviewed
    Yes
    
    Metadata
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    Abstract
    PURPOSE: To investigate cerebrospinal fluid (CSF) dynamics in the aqueduct of Sylvius (AoS) in chronic cerebrospinal venous insufficiency (CCSVI)-positive and -negative healthy individuals using cine phase contrast imaging. MATERIALS AND METHODS: Fifty-one healthy individuals (32 CCSVI-negative and 19 age-matched CCSVI-positive subjects) were examined using Doppler sonography (DS). Diagnosis of CCSVI was established if subjects fulfilled >/=2 venous hemodynamic criteria on DS. CSF flow and velocity measures were quantified using a semiautomated method and compared with clinical and routine 3T MRI outcomes. RESULTS: CCSVI was associated with increased CSF pulsatility in the AoS. Net positive CSF flow was 32% greater in the CCSVI-positive group compared with the CCSVI-negative group (P = 0.008). This was accompanied by a 28% increase in the mean aqueductal characteristic signal (ie, the AoS cross-sectional area over the cardiac cycle) in the CCSVI-positive group compared with the CCSVI-negative group (P = 0.021). CONCLUSION: CSF dynamics are altered in CCSVI-positive healthy individuals, as demonstrated by increased pulsatility. This is accompanied by enlargement of the AoS, suggesting that structural changes may be occurring in the brain parenchyma of CCSVI-positive healthy individuals.
    URI
    http://hdl.handle.net/10454/10606
    Version
    No full-text in the repository
    Citation
    Beggs CB, Shepherd S and Zamboni P (2014) Cerebral venous outflow resistance and interpretation of cervical plethysmography data with respect to the diagnosis of chronic cerebrospinal venous insufficiency. Phlebology. 29(3): 191-199.
    Link to publisher’s version
    https://doi.org/10.1002/jmri.24468
    Type
    Article
    Collections
    Engineering and Digital Technology Publications

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