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    Release behaviour of single pellets and internal fine 3D structural features co-define the in vitro drug release profile

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    Publication date
    2014
    Author
    Yang, S.
    Yin, X.
    Wang, C.
    Li, H.
    He, Y.
    Xiao, T.
    Sun, L.
    Li, J.
    York, Peter
    He, J.
    Zhang, J.
    Show allShow less
    Keyword
    Capsules; Chemistry; Chromatography; Image processing; Imaging; Kinetics; Mass spectrometry; Solubility; Synchrotrons; X-ray microtomography
    Peer-Reviewed
    Yes
    
    Metadata
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    Abstract
    Multi-pellet formulations are advantageous for the controlled release of drugs over single-unit dosage forms. To understand the diffusion controlled drug release mechanism, the pellet structure and drug release from a single pellet (not at dose level) were studied using synchrotron radiation X-ray computed microtomography (SR-muCT) and a sensitive LC/MS/MS method. The purpose of this article is to introduce a powerful, non-invasive and quantitative technique for studying individual pellet microstructures and to investigate the relationship between the microstructure and drug release from single pellets. The data from the single pellet dissolution measurements demonstrated that the release profile of capsules containing approximately 1,000 pellets per unit dose was the summation of the release profiles of the individual pellets. The release profiles of single tamsulosin hydrochloride (TSH) pellets formed three groups when a cluster analysis was performed, and the dissolution rate of the individual pellets correlated well with the combined effects of the drug loading, volume and surface area of the pellets (R(2) = 0.9429). In addition, the void microstructures within the pellet were critical during drug release. Therefore, SR-muCT is a powerful tool for quantitatively elucidating the three-dimensional microstructure of the individual pellets; because the microstructure controls drug release, it is an important parameter in the quality control of multi-pellet formulations.
    URI
    http://hdl.handle.net/10454/10557
    Version
    No full-text available in the repository
    Citation
    Yang S, Yin X, Wang C et al (2014) Release behaviour of single pellets and internal fine 3D structural features co-define the in vitro drug release profile. AAPS Journal. 16(4): 860-871.
    Link to publisher’s version
    https://doi.org/10.1208/s12248-014-9611-x
    Type
    Article
    Collections
    Life Sciences Publications

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