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dc.contributor.authorShahbuddin, M.*
dc.contributor.authorBullock, A.J.*
dc.contributor.authorMacNeil, S.*
dc.contributor.authorRimmer, Stephen*
dc.date.accessioned2016-11-23T17:54:35Z
dc.date.available2016-11-23T17:54:35Z
dc.date.issued2014
dc.identifier.citationShahbuddin M, Bullock AJ, MacNeil S et al (2014) Glucomannan-poly(N-vinyl pyrrolidinone) bicomponent hydrogels for wound healing. Journal of Materials Chemistry B. 2(6): 727-738.
dc.identifier.urihttp://hdl.handle.net/10454/10531
dc.descriptionNo
dc.description.abstractPolysaccharides interact with cells in ways that can be conducive to wound healing. We have recently reported that konjac glucomannan (KGM) which is comprised of D-mannose and D-glucose linked by beta-1,4 glycosidic chains, stimulates fibroblast proliferation. The aim of this study was to produce a range of crosslinked KGMs and bicomponent KGM containing hydrogels and to examine their potential for wound healing. Two types of KGM hydrogel were synthesized, biodegradable from crosslinked KGM and non-biodegradable by forming semi-IPNs and graft-conetworks with a second synthetic component, poly(N-vinyl pyrrolidinone-co-poly(ethyleneglycol) diacrylate) (P(NVP-co-PEGDA)), which was produced by UV initiated radical polymerization. Crosslinked KGM was formed by bimolecular termination of macro-radicals formed by oxidation with Ce(IV). Semi-IPNs were formed by copolymerization of NVP and PEGDA in the presence of KGM and in the graft-conetworks the KGM was also crosslinked using the Ce(IV) procedure. The hydrogels had different swelling properties and differences could be observed in their chemical structure using C-13 solid state NMR, DSC and FTIR. Both forms were cytocompatible but only the graft-conetworks had the ability to stimulate fibroblast metabolic activity and to stimulate the migration of both fibroblasts and keratinocytes. In conclusion a form of KGM hydrogel has been produced that could benefit wound healing.
dc.relation.isreferencedbyhttps://doi.org/10.1039/c3tb21640c
dc.subjectKonjac glucomannan
dc.subject; Drug-delivery
dc.subject; Blend films
dc.subject; Nmr-spectroscopy
dc.subject; Water
dc.subject; Cellulose
dc.subject; Alcohol
dc.subject; State
dc.subject; Acid
dc.subject; Skin
dc.titleGlucomannan-poly(N-vinyl pyrrolidinone) bicomponent hydrogels for wound healing
dc.status.refereedYes
dc.typeArticle
dc.type.versionNo full-text in the repository


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