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    Glucomannan-poly(N-vinyl pyrrolidinone) bicomponent hydrogels for wound healing

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    Publication date
    2014
    Author
    Shahbuddin, M.
    Bullock, A.J.
    MacNeil, S.
    Rimmer, Stephen
    Keyword
    Konjac glucomannan
    ; Drug-delivery
    ; Blend films
    ; Nmr-spectroscopy
    ; Water
    ; Cellulose
    ; Alcohol
    ; State
    ; Acid
    ; Skin
    Peer-Reviewed
    Yes
    
    Metadata
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    Abstract
    Polysaccharides interact with cells in ways that can be conducive to wound healing. We have recently reported that konjac glucomannan (KGM) which is comprised of D-mannose and D-glucose linked by beta-1,4 glycosidic chains, stimulates fibroblast proliferation. The aim of this study was to produce a range of crosslinked KGMs and bicomponent KGM containing hydrogels and to examine their potential for wound healing. Two types of KGM hydrogel were synthesized, biodegradable from crosslinked KGM and non-biodegradable by forming semi-IPNs and graft-conetworks with a second synthetic component, poly(N-vinyl pyrrolidinone-co-poly(ethyleneglycol) diacrylate) (P(NVP-co-PEGDA)), which was produced by UV initiated radical polymerization. Crosslinked KGM was formed by bimolecular termination of macro-radicals formed by oxidation with Ce(IV). Semi-IPNs were formed by copolymerization of NVP and PEGDA in the presence of KGM and in the graft-conetworks the KGM was also crosslinked using the Ce(IV) procedure. The hydrogels had different swelling properties and differences could be observed in their chemical structure using C-13 solid state NMR, DSC and FTIR. Both forms were cytocompatible but only the graft-conetworks had the ability to stimulate fibroblast metabolic activity and to stimulate the migration of both fibroblasts and keratinocytes. In conclusion a form of KGM hydrogel has been produced that could benefit wound healing.
    URI
    http://hdl.handle.net/10454/10531
    Version
    No full-text in the repository
    Citation
    Shahbuddin M, Bullock AJ, MacNeil S et al (2014) Glucomannan-poly(N-vinyl pyrrolidinone) bicomponent hydrogels for wound healing. Journal of Materials Chemistry B. 2(6): 727-738.
    Link to publisher’s version
    https://doi.org/10.1039/c3tb21640c
    Type
    Article
    Collections
    Life Sciences Publications

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