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    Aldehyde dehydrogenases in cancer: an opportunity for biomarker and drug development?

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    Publication date
    2014-12
    Author
    Pors, Klaus
    Moreb, J.S.
    Keyword
    Animals; Antineoplastic agents; Drug discovery; Biomarkers; Humans; Isoenzymes; Antagonists;Neoplasms; Neoplastic stem cells; Aldehyde dehydrogenase
    Peer-Reviewed
    Yes
    
    Metadata
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    Abstract
    Aldehyde dehydrogenases (ALDHs) belong to a superfamily of 19 isozymes that are known to participate in many physiologically important biosynthetic processes including detoxification of specific endogenous and exogenous aldehyde substrates. The high expression levels of an emerging number of ALDHs in various cancer tissues suggest that these enzymes have pivotal roles in cancer cell survival and progression. Mapping out the heterogeneity of tumours and their cancer stem cell (CSC) component will be key to successful design of strategies involving therapeutics that are targeted against specific ALDH isozymes. This review summarises recent progress in ALDH-focused cancer research and discovery of small-molecule-based inhibitors.
    URI
    http://hdl.handle.net/10454/10521
    Version
    No full-text available in the repository
    Citation
    Pors K and Moreb JS (2014) Aldehyde dehydrogenases in cancer: an opportunity for biomarker and drug development? Drug Discovery Today. 19(12): 1953-1963.
    Link to publisher’s version
    https://doi.org/10.1016/j.drudis.2014.09.009
    Type
    Article
    Collections
    Life Sciences Publications

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