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    Controlled delivery of cytokine growth factors mediated by core-shell particles with poly(acrylamidomethylpropane sulphonate) shells

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    Publication date
    2014
    Author
    Platt, L.
    Kelly, L.
    Rimmer, Stephen
    Keyword
    Macro-raft agent
    ; Batch emulsion polymerisation
    ; Styrene
    ; Nanoparticles
    ; Surfactant
    ; Trithiocarbonate
    Peer-Reviewed
    Yes
    
    Metadata
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    Abstract
    Core-shell particles have been prepared by surfactant-free emulsion polymerisations of butyl methacrylate in the presence of either linear or highly branched poly(acrylamidomethylpropane sulphonate)s (L-PAMPS or HB-PAMPS) with dithioate end groups: using a "shell-first" approach. In this method the water soluble PAMPS shells were anchored to the cores by polymerisation of BMA from the chain ends. The linear PAMPS produced non-crosslinked poly(AMPS-BMA) particles but the multiple chain ends of the highly branched PAMPS led to crosslinked particles. The particles were loaded with vascular endothelial growth factor or platelet derived growth factor, both of which are cytokines that are known to be important in the production of new blood vessels. The release of the growth factors was shown to be controlled by the architecture of the shell and we propose a mechanism that involves both ionic interaction of the PAMPS with the heparin-binding domains of the growth factors and size exclusion mediated diffusion.
    URI
    http://hdl.handle.net/10454/10518
    Version
    No full-text in the repository
    Citation
    Platt L, Kelly L and Rimmer S (2014) Controlled delivery of cytokine growth factors mediated by core-shell particles with poly(acrylamidomethylpropane sulphonate) shells. Journal of Materials Chemistry B. 2(5): 494-501.
    Link to publisher’s version
    https://doi.org/10.1039/c3tb21208d
    Type
    Article
    Collections
    Life Sciences Publications

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