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dc.contributor.authorMilner, S.J.*
dc.contributor.authorSnelling, Anna M.*
dc.contributor.authorKerr, Kevin G.*
dc.contributor.authorAbd-El-Aziz, A.*
dc.contributor.authorThomas, G.H.*
dc.contributor.authorHubbard, R.E.*
dc.contributor.authorRoutledge, A.*
dc.contributor.authorDuhme-Klair, A-K.*
dc.date.accessioned2016-11-23T17:53:12Z
dc.date.available2016-11-23T17:53:12Z
dc.date.issued2014
dc.identifier.citationMilner SJ, Snelling AM, Kerr KG et al (2014) Probing linker design in citric acid-ciprofloxacin conjugates. Bioorganic and Medicinal Chemistry. 22(16): 4499-4505.
dc.identifier.urihttp://hdl.handle.net/10454/10512
dc.descriptionNo
dc.description.abstractA series of structurally related citric acid-ciprofloxacin conjugates was synthesised to investigate the influence of the linker between citric acid and ciprofloxacin on antibacterial activities. Minimum inhibitory concentrations (MICs) were determined against a panel of reference strains and clinical isolates of bacteria associated with infection in humans and correlated with the DNA gyrase inhibitory activity. The observed trend was rationalised by computational modelling.
dc.relation.isreferencedbyhttps://doi.org/10.1016/j.bmc.2014.04.009
dc.subjectSiderophore; Citrate; Antibiotic; Computational modelling
dc.titleProbing linker design in citric acid-ciprofloxacin conjugates
dc.status.refereedYes
dc.typeArticle
dc.type.versionNo full-text available in the repository


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