Publication date
2014Author
Milner, S.J.Snelling, Anna M.
Kerr, Kevin G.
Abd-El-Aziz, A.
Thomas, G.H.
Hubbard, R.E.
Routledge, A.
Duhme-Klair, A-K.
Peer-Reviewed
YesOpen Access status
closedAccess
Metadata
Show full item recordAbstract
A series of structurally related citric acid-ciprofloxacin conjugates was synthesised to investigate the influence of the linker between citric acid and ciprofloxacin on antibacterial activities. Minimum inhibitory concentrations (MICs) were determined against a panel of reference strains and clinical isolates of bacteria associated with infection in humans and correlated with the DNA gyrase inhibitory activity. The observed trend was rationalised by computational modelling.Version
No full-text in the repositoryCitation
Milner SJ, Snelling AM, Kerr KG et al (2014) Probing linker design in citric acid-ciprofloxacin conjugates. Bioorganic and Medicinal Chemistry. 22(16): 4499-4505.Link to Version of Record
https://doi.org/10.1016/j.bmc.2014.04.009Type
Articleae974a485f413a2113503eed53cd6c53
https://doi.org/10.1016/j.bmc.2014.04.009