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    Whole-cell Currents Recording from Ion Channels in Human Lymphocytes Treated with Anti-inflammatory Drugs in Nanoparticles Forms

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    Publication date
    2014
    Author
    Shang, Lijun
    Najafzadeh, Mojgan
    Anderson, Diana
    Keyword
    Ion channel; Nanoparticles; Lymphocytes; Ibuprofen; IBU
    Peer-Reviewed
    Yes
    
    Metadata
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    Abstract
    channels that are critical for their development and function. Many ion channels contribute to T cell-mediated autoimmune and/or inflammatory responses, so they are attractive targets for pharmacological immune modulations. In this study, we conduct patch clamp experiments to exam the whole cell currents from lymphocytes after nanoparticles exposure with the aim to test if nanoparticles exposure brings any electrophysiological changes for lymphocytes, and to compare the electrophysiological responses of lymphocytes to drugs in nanoparticles forms. Our result suggests a potential inhibition of effects of IBU N on lymphocytes. Such cytotoxicity of nanoparticles in Lymphocytes may be mainly associated with the early membrane damage. These results are also mirrored by the DNA damages occurred on lymphocytes after exposure of nanoparticles. Further detailed investigation is needed to explain the changes of Lymphocytes in response to NPs in real time and dose differences. This would provide useful information in the evaluation of toxicology of nanoparticles and in understanding the underlying mechanism of their effects on ion channels in health and diseases.
    URI
    http://hdl.handle.net/10454/10485
    Version
    No full-text in the repository
    Citation
    Shang L, Najafzadeh M and Anderson D (2014) Whole-cell Currents Recording from Ion Channels in Human Lymphocytes Treated with Anti-inflammatory Drugs in Nanoparticles Forms. International Journal of Computer, Consumer and Control. 3(3): 11-20.
    Link to publisher’s version
    http://ij3c.ncuteecs.org/volume/3-3.php
    Type
    Article
    Collections
    Life Sciences Publications

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