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dc.contributor.authorZhang, K.*
dc.contributor.authorXu, M.*
dc.contributor.authorSu, J.*
dc.contributor.authorSun, Z.*
dc.contributor.authorLi, Y.*
dc.contributor.authorZhang, W.*
dc.contributor.authorHou, J.*
dc.contributor.authorShang, Lijun*
dc.contributor.authorCui, H.*
dc.date.accessioned2016-11-23T12:21:25Z
dc.date.available2016-11-23T12:21:25Z
dc.date.issued2014
dc.identifier.citationZhang K, Xu M, Su J et al (2014) Characterization and identification of the integrin family in silkworm, Bombyx mori. Gene. 549: 149-155.
dc.identifier.urihttp://hdl.handle.net/10454/10480
dc.descriptionYes
dc.description.abstractAs an important economic insect, Bombyx mori is also a useful model organism for lepidopteran insect. Integrins are evolutionarily conserved fromsponges to humans, and play vital roles inmany physiological and pathological processes. To explore their diverse functions of integrins in insect, eleven integrins including sixα and five β subunitswere cloned and characterized fromsilkworm. Our results showed that integrins fromsilkwormown more family members compared to other invertebrates. Among those α subunits, integrins α1, α2, and the other four subunits belong to PS1, PS2, and PS3 groups, respectively. The β subunits mainly gather in the insect βν group except the β1 subunit which belongs to the insect β group. Expression profiles demonstrated that the integrins exhibited distinct patterns, but were mainly expressed in hemocytes. α1 and β2 subunits are the predominant ones either in the embryogenesis or larva stages. Interestingly, integrins were significantly up-regulated after stimulated by 20-hydroxyecdysone (20-E) in vivo. These results indicate that integrins performdiverse functions in hemocytes of silkworm. Overall, our results provide a newinsight into the functional and evolutionary features of integrins.
dc.description.sponsorshipNational Basic Research Programof China (No. 2012cb114603), the Research Fund for the Doctoral Program of Higher Education of China (20130182110003), the Natural Science Foundation of Chongqing (cstc2013jcyjys0007), and the Fundamental Research Funds for the Central Universities (SWU111014).
dc.language.isoen
dc.rights© 2014 Elsevier. Reproduced in accordance with the publisher's selfarchiving policy. This manuscript version is made available under the CC-BY-NC-ND 4.0 license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
dc.subjectBombyx mori
dc.subjectIntegrin family
dc.subjectEvolutionary analysis
dc.subjectExpression pattern
dc.titleCharacterization and identification of the integrin family in silkworm, Bombyx mori
dc.status.refereedYes
dc.date.Accepted2014-07-23
dc.date.application2014-07-24
dc.typeArticle
dc.type.versionAccepted manuscript
dc.identifier.doihttps://doi.org/10.1016/j.gene.2014.07.060
dc.rights.licenseCC-BY-NC-ND
refterms.dateFOA2018-07-26T09:13:07Z
dc.openaccess.statusopenAccess


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