Show simple item record

dc.contributor.authorBachran, C.*
dc.contributor.authorBachran, S.*
dc.contributor.authorSutherland, Mark H.*
dc.contributor.authorBachran, D.*
dc.contributor.authorFuchs, H.*
dc.date.accessioned2016-11-21T15:53:47Z
dc.date.available2016-11-21T15:53:47Z
dc.date.issued2014
dc.identifier.citationBachran C, Bachran S, Sutherland M et al (2014) Preclinical studies of saponons for tumor therapy. In: Atta-Ur-Rahman and Perry G (Eds) Recent Advances in Medicinal Chemistry. Vol. 1. Bentham Books: Oxford, UK: 272-302.
dc.identifier.urihttp://hdl.handle.net/10454/10421
dc.descriptionNo
dc.description.abstractVarious saponins, plant glycosides with favorable anti-tumorigenic properties, have been used to inhibit tumor cell growth by cell cycle arrest and apoptosis with IC50 values of up to 0.2 μM. We describe several groups of saponins (dioscins, saikosaponins, julibrosides, soy saponins, ginseng saponins and avicins) currently investigated for their use in tumor therapy. We focus on cellular and systemic mechanisms of tumor cell growth inhibition both in vitro and in vivo, combinational approaches with saponins and conventional tumor treatment strategies, and successful syntheses of saponins. The increasing interest in saponins for tumor therapy is very promising for the future development of sophisticated anti-cancer drugs.
dc.relation.isreferencedbyhttps://doi.org/10.2174/97816080579621140101
dc.subjectCancer; Cytotoxicity; Glycoside; Saponin; Steroid; Tumour therapy; Triterpenoid
dc.titlePreclinical studies of saponons for tumor therapy
dc.status.refereedYes
dc.typeBook chapter
dc.type.versionNo full-text available in the repository


This item appears in the following Collection(s)

Show simple item record