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    Male-mediated developmental toxicity

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    Publication date
    2014
    Author
    Anderson, Diana
    Schmid, Thomas E.
    Baumgartner, Adolf
    Keyword
    Animals; Chromatin; Chromosome disorders; DNA; DNA methylation; Epigenomics; Fathers; Histones; Humans; Male; Mice; Minisatellite repeats; Mosaicism; Neoplasms; Paternal exposure; Rats; Smoking; Spermatozoa
    Peer-Reviewed
    Yes
    
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    Abstract
    Male-mediated developmental toxicity has been of concern for many years. The public became aware of male-mediated developmental toxicity in the early 1990s when it was reported that men working at Sellafield might be causing leukemia in their children. Human and animal studies have contributed to our current understanding of male-mediated effects. Animal studies in the 1980s and 1990s suggested that genetic damage after radiation and chemical exposure might be transmitted to offspring. With the increasing understanding that there is histone retention and modification, protamine incorporation into the chromatin and DNA methylation in mature sperm and that spermatozoal RNA transcripts can play important roles in the epigenetic state of sperm, heritable studies began to be viewed differently. Recent reports using molecular approaches have demonstrated that DNA damage can be transmitted to babies from smoking fathers, and expanded simple tandem repeats minisatellite mutations were found in the germline of fathers who were exposed to radiation from the Chernobyl nuclear power plant disaster. In epidemiological studies, it is possible to clarify whether damage is transmitted to the sons after exposure of the fathers. Paternally transmitted damage to the offspring is now recognized as a complex issue with genetic as well as epigenetic components.
    URI
    http://hdl.handle.net/10454/10416
    Version
    No full-text available in the repository
    Citation
    Anderson D, Schmid TE and Baumgartner A (2014) Male-mediated developmental toxicity. Asian Journal of Andrology. 16(1): 81-88.
    Link to publisher’s version
    https://doi.org/10.4103/1008-682X.122342
    Type
    Article
    Collections
    Life Sciences Publications

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