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    In vivo mapping of vascular inflammation using the translocator protein tracer 18F-FEDAA1106

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    Publication date
    2014-08
    Author
    Cuhlmann, S.
    Gsell, W.
    Van der Heiden, K.
    Habib, J.
    Tremoleda, J.L.
    Khalil, M.
    Turkheimer, F.
    Meens, M.J.
    Kwak, B.R.
    Bird, Joseph
    Davenport, A.P.
    Clark, J.
    Haskard, D.
    Krams, R.
    Jones, H.
    Evans, P.C.
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    Keyword
    PET; Peripheral benzodiazepine receptor; FEDAA1106; Vascular inflammation; Carotidartery cuff model
    Rights
    © 2014 Decker Intellectual Properties. This is an Open Access article published under the Creative Commons CC-BY license (http://creativecommons.org/licenses/by/3.0/).
    Peer-Reviewed
    Yes
    
    Metadata
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    Abstract
    Non-invasive imaging methods are required to monitor the inflammatory content of atherosclerotic plaques. FEDAA1106 (N-(5-fluoro-2-phenoxyphenyl)-N-(2-(2-fluoroethoxy)-5- methoxybenzyl) acetamide) is a selective ligand for TSPO-18kDa (also known as peripheral benzodiazepine receptor), which is expressed by activated macrophages. We compared 18F- FEDAA1106 and 18F-FDG (a marker of glucose metabolism) for PET imaging of vascular inflammation. This was tested using a murine model where focal inflammation was induced in the carotid artery via placement of a constrictive cuff. Immunostaining revealed CD68-positive cells (macrophages) at a disturbed flow site located downstream from the cuff. Dynamic PET imaging using 18F-FEDAA1106 or 18F-FDG was registered to anatomical data generated by CT/CT angiography. Standardized uptake values (SUV) were significantly increased at cuffed compared to contralateral arteries using either 18F-FEDAA1106 (p<0.01) or FDG (p<0.05). However, the 18F-FEDAA1106 signal was significantly higher at the inflamed disturbed flow region compared to the non-inflamed uniform flow regions, whereas differences in FDG uptake were less distinct. We conclude that 18F-FEDAA1106 can be used in vivo for detection of vascular inflammation. Moreover, the signal pattern of 18F-FEDAA1106 correlated with vascular inflammation more specifically than FDG uptake.
    URI
    http://hdl.handle.net/10454/10331
    Version
    Published version
    Citation
    Cuhlmann S, Gsell W, Van der Heiden K et al (2014) In vivo mapping of vascular inflammation using the translocator protein tracer 18F-FEDAA. Molecular Imaging. 13: 1-11.
    Link to publisher’s version
    http://dx.doi.org/10.2310/7290.2014.00014
    Type
    Article
    Collections
    Life Sciences Publications

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