Show simple item record

dc.contributor.authorIrkle, A.*
dc.contributor.authorVesey, A.T.*
dc.contributor.authorLewis, D.Y.*
dc.contributor.authorSkepper, J.N.*
dc.contributor.authorBird, Joseph*
dc.contributor.authorDweck, M.R.*
dc.contributor.authorJoshi, F.R.*
dc.contributor.authorGallagher, F.A.*
dc.contributor.authorWarburton, E.A.*
dc.contributor.authorBennett, M.R.*
dc.contributor.authorBrindle, K.M.*
dc.contributor.authorNewby, D.E.*
dc.contributor.authorRudd, J.H.*
dc.contributor.authorDavenport, A.P.*
dc.date.accessioned2016-11-15T10:03:34Z
dc.date.available2016-11-15T10:03:34Z
dc.date.issued2015
dc.identifier.citationIrkle A, Vesey AT, Lewis DY et al (2015) Identifying active vascular microcalcification by 18F-sodium fluoride positron emission tomography. Nature Communications. 6. Article 7495.en_US
dc.identifier.urihttp://hdl.handle.net/10454/10328
dc.descriptionYesen_US
dc.description.abstractVascular calcification is a complex biological process that is a hallmark of atherosclerosis. While macrocalcification confers plaque stability, microcalcification is a key feature of highrisk atheroma and is associated with increased morbidity and mortality. Positron emission tomography and X-ray computed tomography (PET/CT) imaging of atherosclerosis using 18F-sodium fluoride (18F-NaF) has the potential to identify pathologically high-risk nascent microcalcification. However, the precise molecular mechanism of 18F-NaF vascular uptake is still unknown. Here we use electron microscopy, autoradiography, histology and preclinical and clinical PET/CT to analyse 18F-NaF binding. We show that 18F-NaF adsorbs to calcified deposits within plaque with high affinity and is selective and specific. 18F-NaF PET/CT imaging can distinguish between areas of macro- and microcalcification. This is the only currently available clinical imaging platform that can non-invasively detect microcalcification in active unstable atherosclerosis. The use of 18F-NaF may foster new approaches to developing treatments for vascular calcification.en_US
dc.language.isoenen_US
dc.rights© 2015 Macmillan Publishers Limited. This work is licensed under a Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/). The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material.en_US
dc.subjectAtherosclerosis; Calcification; Medical research; Positron-emission tomographyen_US
dc.titleIdentifying active vascular microcalcification by 18F-sodium fluoride positron emission tomographyen_US
dc.status.refereedYesen_US
dc.date.Accepted2015-05-14
dc.date.application2015-07-07
dc.typeArticleen_US
dc.type.versionPublished versionen_US
dc.identifier.doihttps://doi.org/10.1038/ncomms8495
refterms.dateFOA2018-07-26T09:51:44Z


Item file(s)

Thumbnail
Name:
irkle_et_al_2014.pdf
Size:
1.326Mb
Format:
PDF

This item appears in the following Collection(s)

Show simple item record