Identifying active vascular microcalcification by 18F-sodium fluoride positron emission tomography
dc.contributor.author | Irkle, A. | * |
dc.contributor.author | Vesey, A.T. | * |
dc.contributor.author | Lewis, D.Y. | * |
dc.contributor.author | Skepper, J.N. | * |
dc.contributor.author | Bird, Joseph | * |
dc.contributor.author | Dweck, M.R. | * |
dc.contributor.author | Joshi, F.R. | * |
dc.contributor.author | Gallagher, F.A. | * |
dc.contributor.author | Warburton, E.A. | * |
dc.contributor.author | Bennett, M.R. | * |
dc.contributor.author | Brindle, K.M. | * |
dc.contributor.author | Newby, D.E. | * |
dc.contributor.author | Rudd, J.H. | * |
dc.contributor.author | Davenport, A.P. | * |
dc.date.accessioned | 2016-11-15T10:03:34Z | |
dc.date.available | 2016-11-15T10:03:34Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Irkle A, Vesey AT, Lewis DY et al (2015) Identifying active vascular microcalcification by 18F-sodium fluoride positron emission tomography. Nature Communications. 6. Article 7495. | en_US |
dc.identifier.uri | http://hdl.handle.net/10454/10328 | |
dc.description | Yes | en_US |
dc.description.abstract | Vascular calcification is a complex biological process that is a hallmark of atherosclerosis. While macrocalcification confers plaque stability, microcalcification is a key feature of highrisk atheroma and is associated with increased morbidity and mortality. Positron emission tomography and X-ray computed tomography (PET/CT) imaging of atherosclerosis using 18F-sodium fluoride (18F-NaF) has the potential to identify pathologically high-risk nascent microcalcification. However, the precise molecular mechanism of 18F-NaF vascular uptake is still unknown. Here we use electron microscopy, autoradiography, histology and preclinical and clinical PET/CT to analyse 18F-NaF binding. We show that 18F-NaF adsorbs to calcified deposits within plaque with high affinity and is selective and specific. 18F-NaF PET/CT imaging can distinguish between areas of macro- and microcalcification. This is the only currently available clinical imaging platform that can non-invasively detect microcalcification in active unstable atherosclerosis. The use of 18F-NaF may foster new approaches to developing treatments for vascular calcification. | en_US |
dc.language.iso | en | en_US |
dc.rights | © 2015 Macmillan Publishers Limited. This work is licensed under a Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/). The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. | en_US |
dc.subject | Atherosclerosis; Calcification; Medical research; Positron-emission tomography | en_US |
dc.title | Identifying active vascular microcalcification by 18F-sodium fluoride positron emission tomography | en_US |
dc.status.refereed | Yes | en_US |
dc.date.Accepted | 2015-05-14 | |
dc.date.application | 2015-07-07 | |
dc.type | Article | en_US |
dc.type.version | Published version | en_US |
dc.identifier.doi | https://doi.org/10.1038/ncomms8495 | |
refterms.dateFOA | 2018-07-26T09:51:44Z |