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dc.contributor.authorJacob, M.M.*
dc.contributor.authorPangeni, G.*
dc.contributor.authorGomes, B.D.*
dc.contributor.authorSouza, G.S.*
dc.contributor.authorDa Silva Filho, M.*
dc.contributor.authorSilveira, L.C.L.*
dc.contributor.authorMaguire, John*
dc.contributor.authorParry, Neil R.A.*
dc.contributor.authorMcKeefry, Declan J.*
dc.contributor.authorKremers, Jan*
dc.date.accessioned2016-11-07T10:35:12Z
dc.date.available2016-11-07T10:35:12Z
dc.date.issued2015-03-18
dc.identifier.citationJacob MM, Pangeni G, Gomes BD, Souza GS, da Silva Filho M, Silveira LCL, et al. (2015) The Spatial Properties of L- and M-Cone Inputs to Electroretinograms That Reflect Different Types of Post-Receptoral Processing. PLoS ONE. 10(3): e0121218.en_US
dc.identifier.urihttp://hdl.handle.net/10454/10240
dc.descriptionyesen_US
dc.description.abstractWe studied the spatial arrangement of L- and M-cone driven electroretinograms (ERGs) reflecting the activity of magno- and parvocellular pathways. L- and M-cone isolating sine wave stimuli were created with a four primary LED stimulator using triple silent substitution paradigms. Temporal frequencies were 8 and 12 Hz, to reflect cone opponent activity, and 30, 36 and 48 Hz to reflect luminance activity. The responses were measured for full-field stimuli and for different circular and annular stimuli. The ERG data confirm the presence of two different mechanisms at intermediate and high temporal frequencies. The responses measured at high temporal frequencies strongly depended upon spatial stimulus configuration. In the full-field conditions, the L-cone driven responses were substantially larger than the full-field M-cone driven responses and also than the L-cone driven responses with smaller stimuli. The M-cone driven responses at full-field and with 70° diameter stimuli displayed similar amplitudes. The L- and M-cone driven responses measured at 8 and 12 Hz were of similar amplitude and approximately in counter-phase. The amplitudes were constant for most stimulus configurations. The results indicate that, when the ERG reflects luminance activity, it is positively correlated with stimulus size. Beyond 35° retinal eccentricity, the retina mainly contains L-cones. Small stimuli are sufficient to obtain maximal ERGs at low temporal frequencies where the ERGs are also sensitive to cone-opponent processingen_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttp://dx.doi.org/10.1371/journal.pone.0121218en_US
dc.rights© 2015 The Authors. Published by PLOS. Reproduced in accordance with the publisher's self-archiving policy. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_US
dc.subjectElectroretinograms; L- and M-Cone Inputs; Spatial properties; Post-receptoral processingen_US
dc.titleThe Spatial Properties of L- and M-Cone Inputs to Electroretinograms That Reflect Different Types of Post-Receptoral Processingen_US
dc.status.refereedyesen_US
dc.typeArticleen_US
dc.type.versionPublished versionen_US
refterms.dateFOA2018-07-27T02:04:10Z


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