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    Reporting and analyzing alternative clustering solutions by employing multi-objective genetic algorithm and conducting experiments on cancer data

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    Publication date
    2014-01
    Author
    Peng, P.
    Addam, O.
    Elzohbi, M.
    Ozyer, S.
    Elhajj, Ahmad
    Gao, S.
    Liu, Y.
    Ozyer, T.
    Kaya, M.
    Ridley, Mick J.
    Rokne, J.
    Alhajj, R.
    Show allShow less
    Keyword
    Clustering; Genetic algorithm; Gene expression; Data; Multi-objective optimisation; Cluster validity analysis
    Peer-Reviewed
    Yes
    
    Metadata
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    Abstract
    Clustering is an essential research problem which has received considerable attention in the research community for decades. It is a challenge because there is no unique solution that fits all problems and satisfies all applications. We target to get the most appropriate clustering solution for a given application domain. In other words, clustering algorithms in general need prior specification of the number of clus- ters, and this is hard even for domain experts to estimate especially in a dynamic environment where the data changes and/or become available incrementally. In this paper, we described and analyze the effec- tiveness of a robust clustering algorithm which integrates multi-objective genetic algorithm into a frame- work capable of producing alternative clustering solutions; it is called Multi-objective K-Means Genetic Algorithm (MOKGA). We investigate its application for clustering a variety of datasets, including micro- array gene expression data. The reported results are promising. Though we concentrate on gene expres- sion and mostly cancer data, the proposed approach is general enough and works equally to cluster other datasets as demonstrated by the two datasets Iris and Ruspini. After running MOKGA, a pareto-optimal front is obtained, and gives the optimal number of clusters as a solution set. The achieved clustering results are then analyzed and validated under several cluster validity techniques proposed in the litera- ture. As a result, the optimal clusters are ranked for each validity index. We apply majority voting to decide on the most appropriate set of validity indexes applicable to every tested dataset. The proposed clustering approach is tested by conducting experiments using seven well cited benchmark data sets. The obtained results are compared with those reported in the literature to demonstrate the applicability and effectiveness of the proposed approach.
    URI
    http://hdl.handle.net/10454/10196
    Version
    No full-text in the repository
    Citation
    Peng P, Addam O, Elzhohbi M et al (2014) Reporting and analyzing alternative clustering solutions by employing multi-objective genetic algorithm and conducting experiments on cancer data. Knowledge-Based Systems. 56: 108-122.
    Link to publisher’s version
    http://dx.doi.org/10.1016/j.knosys.2013.11.003
    Type
    Article
    Collections
    Engineering and Informatics Publications

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