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dc.contributor.authorMaher, A.
dc.contributor.authorCroker, D.M.
dc.contributor.authorSeaton, Colin C.
dc.contributor.authorRasmuson, Å.C.
dc.contributor.authorHodnett, B.K.
dc.date.accessioned2016-11-02T15:54:27Z
dc.date.available2016-11-02T15:54:27Z
dc.date.issued2014-08-06
dc.identifier.citationMaher A, Corker DM, Seaton CC et al (2014) Solution-Mediated Polymorphic Transformation: Form II to Form III Piracetam in Organic Solvents. Crystal Growth and Design. 14(8): 3967-3974.en_US
dc.identifier.urihttp://hdl.handle.net/10454/10191
dc.descriptionNoen_US
dc.description.abstractThe solution-mediated polymorphic transformation from Form II to Form III 2-oxo-1-pyrrolidine acetamide (piracetam) was investigated in seven organic solvents over the temperature range of 5–50 °C. The transformation rate increased as a function of temperature, agitation, and the solubility of piracetam in the host solvent. However, this trend was reversed in 2-propanol. Molecular modeling demonstrated that 2-propanol forms interactions with piracetam molecules in solution stronger than those formed by other solvents, thereby retarding the nucleation and growth of FIII(6.525) during the transformation in this solvent.en_US
dc.description.sponsorshipSFIen_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttp://dx.doi.org/10.1021/cg500565uen_US
dc.subjectCrystallisation; Nucleation; Polymorphismen_US
dc.titleSolution-Mediated Polymorphic Transformation: Form II to Form III Piracetam in Organic Solventsen_US
dc.status.refereedYesen_US
dc.date.application2014-07-15
dc.typeArticleen_US
dc.type.versionNo full-text in the repositoryen_US


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