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dc.contributor.authorAher, Suyog*
dc.contributor.authorDhumal, Ravindra S.*
dc.contributor.authorMahadik, K.R.*
dc.contributor.authorKetolainen, J.*
dc.contributor.authorParadkar, Anant R*
dc.date.accessioned2016-10-27T15:50:08Z
dc.date.available2016-10-27T15:50:08Z
dc.date.issued2013
dc.identifier.citationAher S, Shumal R, Mahadik K et al (2013) Effect of cocrystallization techniques on compressional properties of caffeine/oxalic acid 2:1 cocrystal. Pharmaceutical Development and Technology. 18(1): 55-60.
dc.identifier.urihttp://hdl.handle.net/10454/10107
dc.descriptionNo
dc.description.abstractCaffeine/oxalic acid 2:1 cocrystal exhibited superior stability to humidity over caffeine, but compressional behavior is not studied yet. To compare compressional properties of caffeine/oxalic acid 2:1 cocrystal obtained by different cocrystallization techniques. Cocrystal was obtained by solvent precipitation and ultrasound assisted solution cocrystallization (USSC) and characterized by X-ray powder diffraction and scanning electron microscopy. Compaction study was carried out at different compaction forces. Compact crushing strength, thickness and elastic recovery were determined. Compaction was in order, caffeine > solvent precipitation cocrystal > USSC cocrystal. Caffeine exhibited sticking and lamination, where solvent precipitation compacts showed advantage. Caffeine and solvent precipitation compacts showed sudden drop in compactability, higher elastic recovery with severe lamination at 20,000 N. This was due to overcompaction. Crystal habit of two cocrystal products was same, but USSC cocrystals were difficult to compact. Uniform needle shaped USSC cocrystals must be difficult to orient in different direction and fracture during compression. Elastic recovery of USSC cocrystals was also more compared to other powders indicating less fracture and poor bonding between particles resulting in poor compaction. Cocrystal formation did not improve compressional property of caffeine. Cocrystals exposed to different crystallization environments in two techniques may have resulted in generation of different surface properties presenting different compressional properties.
dc.language.isoen
dc.subjectCaffeine
dc.subjectChemical precipitation
dc.subjectCrystallisation
dc.subjectDrug compounding
dc.subjectElasticity
dc.subjectMicroscopy
dc.subjectOxalic acid
dc.subjectSolvents
dc.subjectSurface properties
dc.subjectTablets
dc.subjectUltrasonography
dc.subjectX-Ray diffraction
dc.titleEffect of cocrystallization techniques on compressional properties of caffeine/oxalic acid 2:1 cocrystal
dc.status.refereedYes
dc.typeArticle
dc.type.versionNo full-text in the repository
dc.identifier.doihttps://doi.org/10.3109/10837450.2011.618950
dc.openaccess.statusclosedAccess


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