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dc.contributor.authorPandha, H.S.
dc.contributor.authorJaved, S.
dc.contributor.authorSooriakumaran, P.
dc.contributor.authorBott, S.
dc.contributor.authorMontgomery, B.
dc.contributor.authorHutton, A.
dc.contributor.authorEden, C.
dc.contributor.authorLangley, S.E.
dc.contributor.authorMorgan, Richard
dc.date.accessioned2016-10-27T15:45:47Z
dc.date.available2016-10-27T15:45:47Z
dc.date.issued2013-05
dc.identifier.citationPandha H, Javed S, Sooriakumaran P, Bott S, Montgomery B, Hutton A, Eden C, Langley S and Morgan R (2013) Correlation of Urinary Engrailed-2 Levels to Tumour Volume and Pathological Stage in Men Undergoing Radical Prostatectomy. Journal of Cancer Therapy. 4 (3): 726-733.en_US
dc.identifier.urihttp://hdl.handle.net/10454/10105
dc.descriptionyesen_US
dc.description.abstractThe aim of this study was to assess the relationship between pre-prostatectomy urinary Engrailed-2 (EN2), a transcription factor secreted by prostate cancer cells, with tumour volume and pathological characteristics in resected prostate specimens. First pass urine samples (10 ml) without prior prostatic massage were collected and stored at –80°C. EN2 levels were measured using an enzyme-linked immunoabsorbent assay. Tumour volume in the prostatectomy specimens was determined histologically. 57 men undergoing RP in one urological cancer network were evaluated. EN2 was detected in 85% of RP patients. EN2 correlated with tumour volume (but not total prostatic volume) in a linear regression analysis, with increasing pathological T stage and margin positivity. Using three “cutoff levels” of tumour volume (0.5 ml, 1.3 ml and 2.5 ml) to define “significant disease”, men with “significant disease” had markedly higher levels of urinary EN2 (p < 0.001 for each cut off level). Levels of urinary EN2 may be useful in predicting tumour volume in men with prostate cancer by potentially identifying men with small volume “insignificant” disease. This study justifies a larger multicentre evaluation of urinary EN2 levels as a biomarker of PC significance using cancer volume, pathological and PSA criteria.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttp://dx.doi.org/10.4236/jct.2013.43089en_US
dc.rightsCopyright © 2013 The Authors. Published by Scientific Reserch. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
dc.subjectBiomarker; Prostate Cancer; Urineen_US
dc.titleCorrelation of Urinary Engrailed-2 Levels to Tumour Volume and Pathological Stage in Men Undergoing Radical Prostatectomyen_US
dc.status.refereedyesen_US
dc.typeArticleen_US
dc.type.versionPublished versionen_US
refterms.dateFOA2018-07-27T02:03:12Z


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