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    Correlation of Urinary Engrailed-2 Levels to Tumour Volume and Pathological Stage in Men Undergoing Radical Prostatectomy

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    Publication date
    2013-05
    Author
    Pandha, H.S.
    Javed, S.
    Sooriakumaran, P.
    Bott, S.
    Montgomery, B.
    Hutton, A.
    Eden, C.
    Langley, S.E.
    Morgan, Richard
    Keyword
    Biomarker; Prostate Cancer; Urine
    Rights
    Copyright © 2013 The Authors. Published by Scientific Reserch. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
    Peer-Reviewed
    yes
    
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    Abstract
    The aim of this study was to assess the relationship between pre-prostatectomy urinary Engrailed-2 (EN2), a transcription factor secreted by prostate cancer cells, with tumour volume and pathological characteristics in resected prostate specimens. First pass urine samples (10 ml) without prior prostatic massage were collected and stored at –80°C. EN2 levels were measured using an enzyme-linked immunoabsorbent assay. Tumour volume in the prostatectomy specimens was determined histologically. 57 men undergoing RP in one urological cancer network were evaluated. EN2 was detected in 85% of RP patients. EN2 correlated with tumour volume (but not total prostatic volume) in a linear regression analysis, with increasing pathological T stage and margin positivity. Using three “cutoff levels” of tumour volume (0.5 ml, 1.3 ml and 2.5 ml) to define “significant disease”, men with “significant disease” had markedly higher levels of urinary EN2 (p < 0.001 for each cut off level). Levels of urinary EN2 may be useful in predicting tumour volume in men with prostate cancer by potentially identifying men with small volume “insignificant” disease. This study justifies a larger multicentre evaluation of urinary EN2 levels as a biomarker of PC significance using cancer volume, pathological and PSA criteria.
    URI
    http://hdl.handle.net/10454/10105
    Version
    Published version
    Citation
    Pandha H, Javed S, Sooriakumaran P, Bott S, Montgomery B, Hutton A, Eden C, Langley S and Morgan R (2013) Correlation of Urinary Engrailed-2 Levels to Tumour Volume and Pathological Stage in Men Undergoing Radical Prostatectomy. Journal of Cancer Therapy. 4 (3): 726-733.
    Link to publisher’s version
    http://dx.doi.org/10.4236/jct.2013.43089
    Type
    Article
    Collections
    Life Sciences Publications

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