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dc.contributor.authorTronci, G.*
dc.contributor.authorGrant, Colin A.*
dc.contributor.authorThompson, N.H.*
dc.contributor.authorRussell, S.J.*
dc.contributor.authorWood, David J.*
dc.date.accessioned2016-10-25T16:16:57Z
dc.date.available2016-10-25T16:16:57Z
dc.date.issued2014-11
dc.identifier.citationTronci G, Grant CA, Thomson NH et al (2014) Multi-scale mechanical characterization of highly swollen photo-activated collagen hydrogels. Journal of the Royal Society: Interface. 12(102)en_US
dc.identifier.urihttp://hdl.handle.net/10454/10071
dc.descriptionyesen_US
dc.description.abstractBiological hydrogels have been increasingly sought after as wound dressings or scaffolds for regenerative medicine, owing to their inherent biofunctionality in biological environments. Especially in moist wound healing, the ideal material should absorb large amounts of wound exudate while remaining mechanically competent in situ. Despite their large hydration, however, current biological hydrogels still leave much to be desired in terms of mechanical properties in physiological conditions. To address this challenge, a multi-scale approach is presented for the synthetic design of cyto-compatible collagen hydrogels with tunable mechanical properties (from the nano- up to the macro-scale), uniquely high swelling ratios and retained (more than 70%) triple helical features. Type I collagen was covalently functionalized with three different monomers, i.e. 4-vinylbenzyl chloride, glycidyl methacrylate and methacrylic anhydride, respectively. Backbone rigidity, hydrogen-bonding capability and degree of functionalization (F: 16 ± 12–91 ± 7 mol%) of introduced moieties governed the structure–property relationships in resulting collagen networks, so that the swelling ratio (SR: 707 ± 51–1996 ± 182 wt%), bulk compressive modulus (Ec: 30 ± 7–168 ± 40 kPa) and atomic force microscopy elastic modulus (EAFM: 16 ± 2–387 ± 66 kPa) were readily adjusted. Because of their remarkably high swelling and mechanical properties, these tunable collagen hydrogels may be further exploited for the design of advanced dressings for chronic wound care.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttp://dx.doi.org/10.1098/rsif.2014.1079en_US
dc.rights© 2014 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.en_US
dc.subjectPhoto-activated collagen hydrogels; Multi-scale mechanical characterizationen_US
dc.titleMulti-scale mechanical characterization of highly swollen photo-activated collagen hydrogelsen_US
dc.status.refereedYesen_US
dc.typeArticleen_US
dc.type.versionPublished versionen_US
refterms.dateFOA2018-07-27T01:41:45Z


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