Anti-ulcer xanthones from the roots of Hypericum oblongifolium Wall
Ali, M. Latif, A. Zaman, K. Arfan, M. Maitland, Derek J. Ahmad, H. Ahmad, M.
Ali, M.
Latif, A.
Zaman, K.
Arfan, M.
Maitland, Derek J.
Ahmad, H.
Ahmad, M.
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2014
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Abstract
Three new xanthones, hypericorin C (1), hypericorin D (2) and 3,4-dihydroxy-5-methoxyxanthone (3), along with eight known compounds; 2,3-dimethoxyxanthone (4), 3,4-dihydroxy-2-methoxyxanthone (5), 3,5-dihydroxy-1-methoxyxanthone (6), 3-acetylbetulinic acid (7), 10H-1,3-dioxolo[4,5-b]xanthen-10-one (8), 3-hydroxy-2-methoxyxanthone (9), 3,4,5-trihydroxyxanthone (10) and betulinic acid (11) were isolated from the roots of Hypericum oblongifolium. The structures of the new compounds 1, 2 and 3 were deduced by spectroscopic techniques [ESI MS, (1)H NMR, (13)C NMR, and 2D NMR (HMQC, HMBC, COSY and NOESY)]. The entire series of compounds were evaluated for anti-ulcer activity.
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Ali M, Latif A, Zaman K et al (2014) Anti-ulcer xanthones from the roots of Hypericum oblongifolium Wall. Fitoterapia. 95: 258-265.
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