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Fast, facile and solvent‐free dry melt synthesis of oxovanadium(IV) complexes: Simple design with high potency towards cancerous cells
Zegke, Markus Spencer, Hannah L.M. Lord, Rianne M.
Zegke, Markus
Spencer, Hannah L.M.
Lord, Rianne M.
Publication Date
2019-09
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© 2019 Wiley
This is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at https://doi.org/10.1002/chem.201902441. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
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2019-08-06
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Abstract
A range of oxobis(phenyl‐1,3‐butanedione) vanadium(IV) complexes have been successfully synthesized from cheap starting materials and a simple and solvent‐free one‐pot dry‐melt reaction. This direct, straightforward, fast and alternative approach to inorganic synthesis has the potential for a wide range of applications. Analytical studies confirm their successful synthesis, purity and solid‐state coordination, and we report the complexes’ uses as potential drug candidates for the treatment of cancer. After a 24‐hour incubation of A549 lung carcinoma cells with the compounds, they reveal cytotoxicity values 11‐fold greater than cisplatin, and remain non‐toxic towards normal cell types. Additionally, the complexes are stable over a range of physiological pH values and show the potential for interactions with BSA.
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Accepted manuscript
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Zegke M, Spencer HLM and Lord RM (2019) Fast, facile solvent-free dry-melt synthesis of oxovanadium(IV) complexes: Simple design with high potency towards cancerous cells. Chemistry: A European Journal. 25(53): 12275-12280.
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Article