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Stabilisation of metastable polymorphs: the case of paracetamol form III
Telford, Richard Seaton, Colin C. Clout, A. Buanz, A.B.M. Gaisford, S. Williams, G.R. Prior, T.J. Okoye, C.H. Munshi, Tasnim Scowen, Ian J.
Telford, Richard
Seaton, Colin C.
Clout, A.
Buanz, A.B.M.
Gaisford, S.
Williams, G.R.
Prior, T.J.
Okoye, C.H.
Munshi, Tasnim
Scowen, Ian J.
Publication Date
2016
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(c) 2016 The Authors. This is an Open Access article licensed under the Creative Commons CC-BY license (http://creativecommons.org/licenses/by-nc/3.0/)
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openAccess
Accepted for publication
2016-08-05
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Abstract
The design of a melt synthesis of the first air-stable formulation of the metastable form III of paracetamol is derived from thermo-spectroscopic and thermo-diffraction experiments. Melt crystallisation in the presence of β-1,4-saccharides produces form III selectively and the excipients appear to act as stabilising ‘active’ templates of the metastable polymorph.
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Published version
Citation
Telford R, Seaton CC, Clout A et al (2016) Stabilisation of metastable polymorphs: the
case of paracetamol form III. Chemical Communications. Accepted for publication.
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This article is part of themed collection: Pharmaceutical Solids.