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Anticancer activity of electron-deficient metal complexes against colorectal cancer in vitro models

Azmanova, Maria
; 
Soldevila-Barreda, Joan J.
; 
Bani Hani, H.
; 
Lord, Rianne M.
; 
Pitto-Barry, Anaïs
; 
Picksley, Steven M.
; 
Barry, Nicolas P.E.
Publication Date
2019-11-20
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Keywords
Colorectral cancer, Electron-deficient, Gene expression, Half-sandwich complexes, Metallodrugs
Rights
(c) 2019 WileyVCH Verlag GmbH & Co. KGaA, Weinheim. This is the peer-reviewed version of the following article: Azmanova M, Soldevila-Barrera J, Bani Hani H et al (2019) Anticancer activity of electron-deficient metal complexes against colorectal cancer in vitro models' ChemMedChem. 14(22): 1887-1893, which has been published in final form at https://doi.org/10.1002/cmdc.201900528. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
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openAccess
Accepted for publication
2019-09-23
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Life Sciences Publications
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Abstract
An evaluation of the in vitro cytotoxicity of nine electron-deficient half-sandwich metal complexes towards two colorectal cancer cell lines (HCT116 p53+/+, HCT116 p53-/-) and one normal prostate cell line (PNT2) is presented herein. Three complexes were found to be equally cytotoxic towards both colorectal cancer cell lines, suggesting a p53-independent mechanism of action. These complexes are 12 to 34  more potent than cisplatin against HCT116 p53+/+ and HCT116 p53-/- cells. Furthermore, they were found to exhibit little or no cytotoxicity towards PNT2 normal cells, with selectivity ratios greater than 50. To gain an insight into the potential mechanisms of action of the most active compounds, their effects on the expression levels of a panel of genes were measured using qRT-PCR against treated HCT116 p53+/+ and HCT116 p53-/- cells, and cell cycle analysis was carried out.
URI
http://hdl.handle.net/10454/17321
Version
Accepted manuscript
Citation
Azmanova M, Soldevila-Barrera J, Bani Hani H et al (2019) Anticancer activity of electron-deficient metal complexes against colorectal cancer in vitro models. ChemMedChem. 14(22): 1887-1893.
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Link to Version of Record
https://doi.org/10.1002/cmdc.201900528
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Article
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