Thumbnail Image
Publication

Probing the molecular recognition of a DNA-RNA hybrid duplex

Wheelhouse, Richard T.
; 
Garbett, N.C.
; 
Buurma, N.J.
; 
Chaires, J.B.
Publication Date
29/03/2010
End of Embargo
Supervisor
Keywords
DNA, Chemistry, , Ligands, , Molecular Probes, , Molecular structure, , Nucleic Acid Hybridization, , Poly A, , Poly U, , RNA, , REF 2014
Rights
© 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Full-text reproduced in accordance with the publisher's self-archiving policy. This is the peer-reviewed version of the following article: Wheelhouse RT, Garbett NC, Buurma NJ and Chaires JB (2010) Probing the Molecular Recognition of a DNA·RNA Hybrid Duplex. Angewandte Chemie. 49(18): 3207-3210, which has been published in final form at http://dx.doi.org/10.1002/anie.200907235. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving
cb
Peer-Reviewed
Yes
Open Access status
openAccess
Accepted for publication
Institution
Department
Awarded
Embargo end date
Collections
Life Sciences Publications
Show all metadata
Files
Thumbnail Image
wheelhouse_molecular_recognition.pdf
Adobe PDF, 1.31 MB
Additional title
Abstract
Curiouser and curiouser! A biarylpyrimidine ligand (see picture: N blue, H cyan, S yellow) shows a marked structure and sequence selectivity for the poly(dA)â‹…poly(rU) hybrid duplex. An intercalative binding site was discovered where the ligand occupies a surprising ten base pairs. A strong correlation between hybrid duplex and DNA triplex binding indicates new directions for ligand design.
URI
http://hdl.handle.net/10454/6233
Version
Accepted manuscript
Citation
Wheelhouse RT, Garbett NC, Buurma NJ and Chaires JB (2010) Probing the molecular recognition of a DNA-RNA hybrid duplex. Angewandte Chemie International Edition. 49(18): 3207-3210.
Link to publisher’s version
Link to published version
Link to Version of Record
https://doi.org/10.1002/anie.200907235
Type
Article
Qualification name
Notes