Loading...
Stem Cell Niche Microenvironment: Review
Abdul-Al, Mohamed Kyeremeh, George K. Saeinasab, M. Heidari Keshel, S. Sefat, Farshid
Abdul-Al, Mohamed
Kyeremeh, George K.
Saeinasab, M.
Heidari Keshel, S.
Sefat, Farshid
Publication Date
2021-07-28
End of Embargo
Supervisor
Rights
© 2021 the Authors. Licensee MDPI, Basel, Switzerland.
This article is an open access article distributed under the terms and conditions of the
Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)
Peer-Reviewed
yes
Open Access status
Gold
Accepted for publication
2021-07-16
Institution
Department
Awarded
Embargo end date
Additional title
Abstract
The cornea comprises a pool of self‐regenerating epithelial cells that are crucial to preserving
clarity and visibility. Limbal epithelial stem cells (LESCs), which live in a specialized stem cell
niche (SCN), are crucial for the survival of the human corneal epithelium. They live at the bottom
of the limbal crypts, in a physically enclosed microenvironment with a number of neighboring niche
cells. Scientists also simplified features of these diverse microenvironments for more analysis in situ
by designing and recreating features of different SCNs. Recent methods for regenerating the corneal
epithelium after serious trauma, including burns and allergic assaults, focus mainly on regenerating
the LESCs. Mesenchymal stem cells, which can transform into self‐renewing and skeletal tissues,
hold immense interest in tissue engineering and innovative medicinal exploration. This review
summarizes all types of LESCs, identity and location of the human epithelial stem cells (HESCs),
reconstruction of LSCN, and artificial stem cells for self‐renewal.
Version
Published version
Citation
Abdul-Al M, Kyeremeh GK, Saeinasab M, Heidari Keshel S and Sefat F (2021) Stem Cell Niche Microenvironment: Review. Bioengineering. 8(8): 108.
Link to publisher’s version
Link to published version
Link to Version of Record
Type
Article