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Stem Cell Niche Microenvironment: Review
Abdul-Al, Mohamed Kyeremeh, George K. Saeinasab, M. Heidari Keshel, S. Sefat, Farshid
Abdul-Al, Mohamed
Kyeremeh, George K.
Saeinasab, M.
Heidari Keshel, S.
Sefat, Farshid
Publication Date
2021-07-28
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Rights
Š 2021 the Authors. This is an Open Access article distributed under the Creative Commons CC-BY license (http://creativecommons.org/licenses/by/4.0/)
Peer-Reviewed
Yes
Open Access status
openAccess
Accepted for publication
2021-07-16
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Abstract
The cornea comprises a pool of selfâregenerating epithelial cells that are crucial to preserving clarity and visibility. Limbal epithelial stem cells (LESCs), which live in a specialized stem cell niche (SCN), are crucial for the survival of the human corneal epithelium. They live at the bottom of the limbal crypts, in a physically enclosed microenvironment with a number of neighboring niche cells. Scientists also simplified features of these diverse microenvironments for more analysis in situ by designing and recreating features of different SCNs. Recent methods for regenerating the corneal epithelium after serious trauma, including burns and allergic assaults, focus mainly on regenerating the LESCs. Mesenchymal stem cells, which can transform into selfârenewing and skeletal tissues, hold immense interest in tissue engineering and innovative medicinal exploration. This review
summarizes all types of LESCs, identity and location of the human epithelial stem cells (HESCs), reconstruction of LSCN, and artificial stem cells for selfârenewal.
Version
Published version
Citation
Abdul-Al M, Kyeremeh GK, Saeinasab M, Heidari Keshel S and Sefat F (2021) Stem Cell Niche Microenvironment: Review. Bioengineering. 8(8): 108.
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Article