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Continuous Manufacturing of Cocrystals Using Solid State Shear Milling Technology
Korde, Sachin A. Pagire, Sudhir K. Pan, H. Seaton, Colin C. Kelly, Adrian L. Chen, Y. Wang, Q. Coates, Philip D. Paradkar, Anant R
Korde, Sachin A.
Pagire, Sudhir K.
Pan, H.
Seaton, Colin C.
Kelly, Adrian L.
Chen, Y.
Wang, Q.
Coates, Philip D.
Paradkar, Anant R
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Publication Date
2018
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© 2018 ACS. This document is the Accepted Manuscript version of a Published Work that appeared in final form in Crystal Growth and Design after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.cgd.7b01733.
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openAccess
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2018-03-13
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Abstract
Solid state shear milling (S3M) is reported as a scalable, continuous, polymer-assisted cocrystallization technique. A specially designed milling pan was employed to provide high levels of applied shear, and the addition of a polymeric processing aid enabled generation of high stress fields. Carbamazepine–salicylic acid cocrystals were produced with 5–25 wt % of poly(ethylene oxide) (PEO). A systematic study was carried out to understand the effect of process variables on properties and performance of the cocrystals. S3M offers an important new route for continuous manufacturing of pharmaceutical cocrystals.
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Accepted manuscript
Citation
Korde S, Pagire S, Pan H et al (2018) Continuous Manufacturing of Cocrystals Using Solid State Shear Milling Technology. Crystal Growth & Design. 18(4): 2297-2304.
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Article