p53/p63/p73 in the Epidermis in Health and Disease
Botchkarev, Vladimir A. Flores, E.R.
Botchkarev, Vladimir A.
Flores, E.R.
Publication Date
2014
End of Embargo
Supervisor
Rights
Peer-Reviewed
Yes
Open Access status
closedAccess
Accepted for publication
Institution
Department
Awarded
Embargo end date
Collections
Abstract
Although p53 has long been known as the “guardian of the genome” with a role in tumor suppression in many tissues, the discovery of two p53 ancestral genes, p63 and p73, more than a decade ago has triggered a considerable amount of research into the role of these genes in skin development and diseases. In this review, we primarily focus on mechanisms of action of p53 and p63, which are the best-studied p53 family members in the skin. The existence of multiple isoforms and their roles as transcriptional activators and repressors are key to their function in multiple biological processes including the control of skin morphogenesis, regeneration, tumorigenesis, and response to chemotherapy. Last, we provide directions for further research on this family of genes in skin biology and pathology.
Version
No full-text in the repository
Citation
Botchkarev VA and Flores ER (2014) p53/p63/p73 in the epidermis in health and disease. Cold Spring Harbour Perspectives in Medicine. 4(8): a015248.
Link to publisher’s version
Link to published version
Link to Version of Record
Type
Article