Loading...
Disease map-based biomarker selection and pre-validation for bladder cancer diagnostic
De Paoli, M. Perco, P. Mühlberger, I. Lukas, A. Pandha, H.S. Morgan, Richard Feng, G.J. Marquette, C.
De Paoli, M.
Perco, P.
Mühlberger, I.
Lukas, A.
Pandha, H.S.
Morgan, Richard
Feng, G.J.
Marquette, C.
Publication Date
31/07/2015
End of Embargo
Supervisor
Rights
© 2015 Taylor & Francis. This is an Author's Original Manuscript of an article published by Taylor & Francis in Biomarkers on 31 Jul 2015, available online at http://www.tandfonline.com/10.3109/1354750X.2015.1068867
Peer-Reviewed
Yes
Open Access status
openAccess
Accepted for publication
10/06/2015
Institution
Department
Awarded
Embargo end date
Collections
Additional title
Abstract
Context: Urinary biomarkers are promising as simple alternatives to cystoscopy for the diagnosis of de novo and recurrent bladder cancer.
Objective: To identify a highly sensitive and specific biomarker candidate set with potential clinical utility in bladder cancer.
Materials and methods: Urinary biomarkers concentrations were determined by ELISA. The performance of individual markers and marker combinations was assessed using ROC analysis.
Results: A 5-biomarker panel (IL8, MMP9, VEGFA, PTGS2 and EN2) was defined from the candidate set.
Discussion and conclusion: This panel showed a better overall performance than the best individual marker. Further validation studies are needed to evaluate its clinical utility in bladder cancer.
Version
Accepted manuscript
Citation
De Paoli M, Perco P, Mühlberger I et al. (2015) Disease map-based biomarker selection and pre-validation for bladder cancer diagnostic. Biomarkers. 20(5): 328-337.
Link to publisher’s version
Link to published version
Link to Version of Record
Type
Article