An experimental and computational study on the epimeric contribution to the infrared spectrum of budesonide
Ali, H.R.H. Edwards, Howell G.M. Kendrick, John Munshi, Tasnim Scowen, Ian J.
Ali, H.R.H.
Edwards, Howell G.M.
Kendrick, John
Munshi, Tasnim
Scowen, Ian J.
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2010
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Abstract
Budesonide is a mixture of 22R and 22S epimers. The epimeric content of budesonide was reported in both British and European pharmacopoeias to be within the range of 60-49/40-51 for R and S epimers, respectively. In this work, contribution of the two epimers to the overall infrared spectrum of budesonide has been investigated by quantum chemical calculations.
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Ali, H.R.H., Edwards, H.G.M., Kendrick, J., Munshi, T. and Scowen, I.J. (2010). An experimental and computational study on the epimeric contribution to the infrared spectrum of budesonide. Drug Testing and Analysis. Vol. 2, No. 9, pp. 447¿451.
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