Artemisinin-acetylenedicarboxylic acid cocrystal: Screening, structure determination, and physicochemical property characterisation
Makadia, J. Madu, S.J. Arroo, R. Li, M.
Makadia, J.
Madu, S.J.
Arroo, R.
Li, M.
Publication Date
2022
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© The Royal Society of Chemistry 2022. Reproduced in accordance with the publisher's self-archiving policy.
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2021-12-23
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Abstract
Artemisinin is used to treat multi-drug resistant strains of malaria and is also in the early stages of development as an anti-cancer drug. However, the usage of artemisinin is limited due to its low aqueous solubility. Herein a large scale cocrystal screening of artemisinin was conducted using both computational and experimental approaches, leading to a new 2 : 1 artemisinin and acetylenedicarboxylic acid (ART2-ACA) cocrystal. ART2-ACA crystallises in the P212121 space group of the orthorhombic system with cell parameters a = 10.5089 Å, b = 24.083 Å, and c = 6.4952 Å. The asymmetric unit of the cocrystal contains two ART molecules and a single ACA molecule, assembled into discrete trimeric units held together by two supramolecular heterosynthons. It was shown that ART2-ACA cocrystals have higher solubility and a faster dissolution rate compared to the parent drug artemisinin. This journal is
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Makadi J, Madu SJ, Arroo R et al (2022) Artemisinin-acetylenedicarboxylic acid cocrystal: Screening, structure determination, and physicochemical property characterisation. CrystEngComm. 24(5): 1056-1067.
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