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MMP-9 triggered micelle-to-fibre transitions for slow release of doxorubicin
Kalafatovic, D. Nobis, M. Javid, Nadeem Frederix, P.W.J.M. Anderson, K.I. Saunders, B.R. Ulijn, R.V.
Kalafatovic, D.
Nobis, M.
Javid, Nadeem
Frederix, P.W.J.M.
Anderson, K.I.
Saunders, B.R.
Ulijn, R.V.
Publication Date
2014-10-28
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(c) 2015 The Authors. This is an Open Access article distributed under the Creative Commons CC-BY license (http://creativecommons.org/licenses/by/3.0/)
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openAccess
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2014-10-09
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Abstract
Phenylacetyl-peptide amphiphiles were designed, which upon cleavage by a disease-associated enzyme reconfigure from micellar aggregates to fibres. Upon this morphological change, a doxorubicin payload could be retained in the fibres formed, which makes them valuable carriers for localised formation of nanofibre depots for slow release of hydrophobic anticancer drugs.
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Published version
Citation
Kalafatovic D, Nobis M, Javid N et al (2015) MMP-9 triggered micelle-to-fibre transitions for slow release of doxorubicin. Biomaterials Sciences. 3(2): 246-249.
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